Animal modeling is a crucial necessity in clinical studies of liver diseases. Authenticity of the data which are produced using this tool under different conditions and accuracy of the analyses and assessments which would be based on such data sets is completely dependent on the adoption of a standardized methodology for analyzes and assessment of these data sets. Cirrhosis and Fibrosis are amo...
The pediatric liver transplant evolved in the 1980s and became established in the 1990s. First successful pediatric liver transplant was performed in 1967 by Prof. Starlz. . There were rapid advances in adult transplantation throughout the 1970s. 1986, when most adult units claimed a 1 year survival rate of 80% average 1 year survival rates in children were only 60% (1). Since then, there have ...
Acute hepatic failure is characterized by jaundice and hepatic encephalopathy within eight weeks after the onset of disease. Although acute hepatic failure is a rare occurrence, its rapid progression and high mortality (50 to 90%, depending on the etiology of disease) necessitate immediate intervention. In the absence of causal therapy, orthotopic liver transplantation is currently the only def...
Assessment of liver histology following orthotopic liver transplantation is an essential component of management in the transplant recipient. Most programs recommend liver biopsies when there are changes in the patient’s status or biochemical tests. The use of protocol allograft biopsies, that is in asymptomatic recipients with normal or near-normal liver tests, is controversial. Considerations...
I N this communication we will discuss three questions about orthotopic liver transplantation (liver replacement). First, what are the indications for hepatic transplantation? Second, what have been the results? Third, what is the outlook for improving these figures? Orthotopic liver transplantation is often difficult, mainly because of the liver pathology that essentially always creates severe...
Alcohol consumption, in particular harmful alcohol use related to Alcohol Use Disorders (AUD) accounts for 3.8% of global mortality and 4.6% of Disability-Adjusted Life Years (DALYs) worldwide . A total of 9.5% of alcohol-related DALYs is due to Alcoholic Liver Disease (ALD) . At present alcohol still represents the most common cause of liver cirrhosis in the Western countries . The de...
R E Stauber,
J S Gavaler,
M H Basista,
V J Dindzans,
R R Schade,
R E Tarter,
T E Starzl,
Alcohol abuse is the most common cause of end-stage liver disease in the United States, but many transplant centers are unwilling to accept alcoholic patients because of their supposed potential for recidivism, poor compliance with the required immunosuppression regimen and resulting failure of the allograft. There is also concern that alcohol-induced injury in other organs will preclude a good...
however, history of liver transplantation has started in 1963, but after discovery of anti-rejection drugs such as cyclosporine in 1980s, this method has experienced. from 1984 more than 3000 patients underwent surgery and just 1680 patients in 66 liver transplantation centers have operated in 1988. every patient suffers from severe liver diseases and is in terminal stage of this disease, must ...