Objective(s): As a multifunctional molecule, NO has different effects on liver injury. The present work aimed to investigate the effects of Nos2 knockout (KO) on acute liver injury in aged mice treated with carbon tetrachloride (CCl4). Materials and Methods: The acute liver injury model was produced by CCl4 at 10 ml/kg body weight in 24-...

objective: to evaluate the effect of fibrin perihepatic packing on controlling liver hemorrhage and liver wound healing. methods: in this animal experimental study, 20 adult male sprague dawley rats, weighing 200-220 g, were included. stab wound injury was created by number 15 scalpel, so that bilateral liver capsules and liver tissue were cut, and acute bleeding was accrued. the animals were d...

objective: to evaluate the hepatoprotective properties of otostegia persica (o. persica) ethanol extract on carbon tetrachlo­­ride-induced liver damage in rats. materials and methods: fifty adult male wistar rats were randomly divided into five groups. group i served as normal control and was given only olive oil intraperitoneally (i.p.). group ii, iii, iv, and v were administered ccl4 mixed wi...

background evaluation of a transplanted liver by imaging techniques and enzyme changes is sensitive to hepatocellular or biliary problems, but in most instances liver allograft biopsies are performed in order to find out the final reason for these changes. objectives it’s been about 17 years (with more than 1326 cases) since the first liver transplantation in the namazi hospital of shiraz unive...

Herb Induced Liver Injury (HILI) is a condition in which there aggression to the liver tissue after exposure substances present many different medications, dietary supplements, herbs and xenobiotics.

nigella sativa (family ranunculaceae) is a widely used medicinal plant throughout the world. n. sativa is referred in the middle east as a part of an overall holistic approach to health. pharmacological properties of n. sativa including immune stimulant, hypotensive, anti-inflammatory, anti-cancer, antioxidant, hypoglycemic, spasmolytic and bronchodilator have been shown. reactive oxygen specie...

Objective(s): Liver transplantation is the most important therapy for end-stage liver disease and ischemia reperfusion (I/R) injury is indeed a risk factor for hepatic failure after grafting. The role of miRNAs in I/R is not completely understood. The aim of this study was to investigate the potential protective role of the mesenchymal stem cells (MSCs) and ischemic pr...

Liver ischemia and reperfusion (IR) injury is the major complication of liver-related operations. Macrophage polarization has an essential effect on mechanism liver IR injury. Vitamin D receptor (VDR) been found to regulate macrophage alleviate Nevertheless, correlation between VDR in not clearly elucidated. knockout mice wild-type littermates underwent partial for 90 min 6 h. RAW264.7 cells we...

Background: Extend of lung injury, inflammation due to SARS COV-2 can also cause liver injury. Liver injury in COVID-19 patients be caused by the direct effect on liver, cholangiocyte role, activation immune system, drug-induced and hypoxic Hepatocyte necrosis could increase transaminase. Therefore, transaminase may reveal severity. Aim: This study aims know relationship severity mortality pati...

Background: Long-term use of levofloxacin can cause alterations in the liver function. This study aimed to determine the protective effect of black seed oil (BSO) against liver injury due to levofloxacin administration in rats. Methods: The chemical composition of BSO was analyzed with gas chromatography and mass spectrophotometry (GC-MS). Rats (n=30) were treated daily with levofloxacin and ...