background: despite extensive progress in ivf techniques, one of the most difficult problems is the variability in the response to controlled ovarian hyperstimulation (coh). recent studies show the effects of individual genetic variability on coh outcome. objective: to evaluate the correlation between lhβ g1502a polymorphisms in exon 3 of the lh gene and ovarian response to coh. materials and m...

background: despite the impressive results obtained with imatinib, inadequate response or resistance are observed in certain patients. it is known that imatinib is a substrate of a multidrug resistance gene (mdr1). thus, interindividual genetic differences linked to single nucleotide polymorphisms in mdr1 may influence the metabolism of imatinib. the present study has aimed to examine the impac...

lenged with PDE developed extensive interstitial infiltrations of macrophages and multinucleated giant cells that were most prominent around respiratory bronchioles but also extended into the alveolar septa. There were also associated perivascular lymphocytic and plasma cell infiltrates. Neither immunization nor aerosol challenge per se resulted in pulmonary inflammation. In contrast, C57BL/10 ...

Background: Different studies have demonstrated that a small proportion of healthy individuals receiving the hepatitis B (HB) vaccine do not produce protective levels of anti-HB antibody, a phenomenon which could be linked to certain human leukocyte an-tigen (HLA) class-II alleles or haplotypes. Objectives: The present study was under-taken to determine the frequency of HLA class-II alleles in ...

Background Methadone therapy is a major protocol in opioid addiction cases in many health care systems. Population-based studies have shown that in addicted people, the genetic profile affects their response to methadone therapy. Therefore, this study designed to examine the frequency of two SNPs of the CYP2B6 gene (rs3745274 and rs3211371) in addicted cases in two methadone-responders and meth...

OBJECTIVE To compare a recently developed immunoprecipitation assay (IPA) to the mouse protection bioassay (MPB), currently considered the "gold standard", for detecting antibodies against botulinum toxin A (BTX-A) and to correlate these assay results with clinical responses to BTX-A injections. METHODS MPB and IPA assays were performed on serum samples from 83 patients (38 non-responders, 45...

background: anti-mullerian hormone (amh) is constantly secreted during menstrual cycles and may offer several advantages over traditional biomarkers of ovarian reserve. objective: to assess the relationship of anti-mullerian hormone (amh) values, which are used to evaluate ovary reserves, with oocyte and embryo quality and with art outcomes in patients undergoing intra-cytoplasmic sperm injecti...

BACKGROUND The large placebo effect observed in prior acupuncture trials presents a substantial challenge for interpretation of the efficacy of acupuncture. We sought to evaluate the relationship between response expectancy, a key component of the placebo effect over time, and treatment outcome in real and sham electroacupuncture (EA). METHODS We analyzed data from a randomized controlled tri...