immunoglobulin class switch recombination deficiencies (ig csr deficiencies) or hyper igm syndromes (higm) are a group of primary immunodeficiency diseases, characterized by defective cd40 signaling of b cells resulting into a csr and a somatic hypermutation. the affected patients are characterized with reduced serum levels of igg and iga, and normal or elevated level of igm, which lead to incr...

CXL (Compute Express Link) technology is a relatively new high-speed interconnect standard that was developed to enable faster communication between CPUs, GPUs, and other high-performance components in data center systems. This paper aims provide comprehensive technical overview of technology, including its features, advantages, potential applications the modern environment. Technology Research...

A packet-based least cushion first/most urgent first (PB-LCF/MUF) maximal matching algorithm is presented in this paper for combined input and output queued (CIOQ) switches with multiple traffic classes. The main benefit of using a CIOQ switch is to alleviate memory bandwidth requirement while providing quality of service (QoS) guarantee. It was proved that, with a speedup factor of 2, a CIOQ s...

Cache coherentnon-uniform memory access (CC-NUMA) multiprocessors continue to suffer from remote memory access latencies due to comparatively slow memory technology and data transfer latencies in the interconnection network. In this paper, we propose a novel hardware caching technique, called switch cache. The main idea is to implement small fast caches in crossbar switches of the interconnect ...

This paper presents a novel RF MEMS (Micro Electromechanical System) fixed-fixed switch for very fast switching. Using the obtained equations, the switching time depends on the stiffness and effective mass of the switch beam so that the switching time will be decreased by higher stiffness (spring constant) and lower effective mass. In new design, the suspension bridge is a three-layer beam so t...

One of the best vibration control methods using smart actuators are semi-active approaches which are as strong as active methods and need no external energy supply such as passive ones. Compared with piezoelectric-based, magnetostrictive-based control methods have higher coupling efficiency, higher Curie temperature, higher flexibility to be integrated with curved structures and no depolarizati...

Biosensors draw inspiration from natural chemosensing based on molecular switches between different bond-induced conformational states. Proteins and nucleic acids can be adapted into switch-based biosensors with a wide plethora of configurations, taking advantage the variety transduction systems, optical to electrochemical or electrochemiluminescence, as well nanomaterials for signal augmentati...