background : non-alcoholic steatohepatitis (nash) is a common liver disease that, in the absence of treatment may progress to cirrhosis. there is a strong association of nash with insulin resistance; thus insulin sensitizer drugs have been used for this disease. the aim of this study was to compare the effect of pioglitazone with metformin on liver transaminases, the homa index, and adiponectin...

background: considering the increasing trend of obesity, especially in developing countries such as iran, and the role of inflammatory factors and insulin resistance (ir) in the occurrence of obesity?related complications as well as the safety of some agents such as folic acid and metformin, this clinical trial was designed to investigate the effect of metformin and folic acid on inflammatory f...

introduction: non-alcoholic fatty liver is one of the most prevalent digestive diseases in the world and its prevalence is increasing rapidly. the objective of this study was to compare the treatment effect of pioglitazone and metformin on fatty liver. materials and methods: this double blinded clinical trial study was performed in 2012 among patients referring to gastrointestinal clinics in th...

microalbuminuria is thought to reflect the severity of inflammation-induced systemic vascular permeability. the present study investigated the effect of early administration of metformin or insulin on microalbuminuria in traumatized critically ill patients. between april 2006 and october 2007, thirty-one non-diabetics traumatized patients with systemic inflammatory response syndrome (sirs) and ...

UNLABELLED The risks and benefits of metformin use in patients with cirrhosis with diabetes are debated. Although data on a protective effect of metformin against liver cancer development have been reported, metformin is frequently discontinued once cirrhosis is diagnosed because of concerns about an increased risk of adverse effects of metformin in patients with liver impairment. This study in...

Our clinical study indicates esophageal adenocarcinoma patients on metformin had a better treatment response than those without metformin. However, the effects of metformin and the mechanisms of its action in esophageal cancer (EC) are unclear. EC cell lines were used to assess the effects of metformin alone or in combination with 5-fluorouracil on survival and apoptosis. RPPA proteomic array a...

conclusions compared with acarbose or metformin monotherapy, the addition of acarbose to metformin had superior antihyperglycemia efficacy and provided an efficacious and safe alternative for the treatment of type 2 diabetic rats. acarbose/metformin reduced the fasting blood glucose and glycated hemoglobin without significant changes in serum visfatin levels. background diabetes mellitus is a c...

Type 2 diabetes mellitus is a worldwide epidemic disorder with considerable health and economic consequences. Metformin is one of the most commonly prescribed oral antidiabetic drugs. Pharmacogenetic studies showed that variants in genes related to the pharmacokinetics of metformin were associated with glucose-lowering effect of metformin. The aim of this study was to evaluate pharmacogenetic v...

INTRODUCTION Saxagliptin added to metformin extended release (XR) and uptitrated metformin XR were evaluated for their impact on daily glucose measurements and their tolerability in patients with type 2 diabetes mellitus (T2DM) inadequately controlled with metformin monotherapy. METHODS Patients aged 18-78 years on metformin 850-1,500 mg with glycated hemoglobin (HbA1c) 7.5-11.5% at screening...