Laminins regulate diverse cellular functions through interaction with integrins. Two regions of laminins-three laminin globular domains of the α chain (LG1-3) and the carboxyl-terminal tail of the γ chain (γ-tail)-are required for integrin binding, but it remains unclear how the γ-tail contributes to the binding. We determined the crystal structure of the integrin binding fragment of laminin-51...

The association of microphthalmia and linear skin defects was named microphthalmia with linear skin defects syndrome (MLS) or MIDAS syndrome (microphthalmia, dermal aplasia, and sclerocornea), an X-chromosomal disorder manifesting mainly in females. We examined a female newborn with facial linear skin defects following the Blaschko lines. Computer tomography and ophthalmological examination con...

Managers of electronic commerce sites need to learn as much as possible about their customers and those browsing their virtual premises, in order to maximise the return on marketing expenditure. The discovery of marketing related navigation patterns requires the development of data mining algorithms capable of the discovery of sequential access patterns from web logs. This paper introduces a ne...

Bu çalışmada, Ocak 2005-Kasım2020 dönemleri arasında Türkiye’de Gösterge Borsa Endeksi’nin (BİST100) makro ekonomik büyümeye etkisinin incelenmesi amaçlanmıştır. amaçla büyüme göstergesi olarak Gayri Safi Yurt İçi Hasıla verileri çeyrek dönemlik analize dahil edilmiştir. Bist100 endeksi ise aylık kullanılmıştır. Analiz karma veri örnekleme metodu (MİDAS Mixed Data Sampling) kullanılarak yapılmı...

The diet of Saguinus midas is characterised by analysis of stomach contents samples on an annual and seasonal basis. The diet comprises significant proportions of both fruit and insects all year round, although fruit use shows important seasonal variations. The tamarins reduce their use of fruit resources during the peak fruiting season and instead exploit increased opportunities for insectivor...

This paper introduces Mixed Data Sampling (MIDAS) into the panel data context. To address unidentified nuisance parameter problem, we propose to invert model specification tests for inference on MIDAS along with bounds coefficients. Illustrative identification, simulation and empirical analyses are conducted in dynamic GMM framework. Our framework allows departures from i.i.d errors such as clu...

The aim of this study is to investigate the herding beta transmission between return and volatility. We have used dynamic conditional correlation model with mixed-data sampling (DCC-MIDAS) for analysis. evidence demonstrates that a key transmitter in Taiwan’s stock market. significant estimation DCC-MIDAS explains phenomenon highly time-varying behavior. By means based on our rolling forecastin...