Myostatin is a growth factor belonging to the TGFß superfamily. TGFß growth factors are active in the regulation of embryonic development and in tissue homeostasis in adults. Myostatin is a growth factor controlling proliferation of myoblasts in embryonic development. Mutations in coding sequences of the bovine myostatin (GDF8) gene lead to muscle hyperplasia suggesting its inhibitory function ...

myostatin is a growth factor belonging to the tgfß superfamily. tgfß growth factors are active in the regulation of embryonic development and in tissue homeostasis in adults. myostatin is a growth factor controlling proliferation of myoblasts in embryonic development. mutations in coding sequences of the bovine myostatin (gdf8) gene lead to muscle hyperplasia suggesting its inhibitory function ...

the aim of the current study is to amplification the regularity region encompassed the mutations changing the myostatin gene express and also to determine sequential analysis. the blood samples taken from 12 najdi cattles in najdi cattle station in shushtar city, khuzestan province. then the dna extracted to amplification 730bp and 561bp fragments. sequencing was performed after the precision i...

Background and Objectives: Muscular atrophy is one of the indicators of uncontrolled diabetes. The aim of the current study was to investigate effects of eight weeks of resistance training (RT) on myostatin gene expression in soleus muscles and insulin resistance in streptozotocin (STZ)-induced diabetic rats. Materials and Methods: In general, 14 Wistar male rats weighing 200–250 g and aging 8...

Myostatin is a negative regulator of the growth and development of skeletal muscle mass. In fish, myostatin is expressed in several organs in addition to skeletal muscle. To understand the mechanisms regulating myostatin gene expression in the sea perch, Lateolabrax japonicus, we examined the methylation status of the myostatin gene promoter region in several tissues (liver, eye, kidney, brain,...

Myostatin is a recently discovered gene that inhibits muscle growth. In the present study, we characterized the myostatin locus and its expression in channel catfish (Ictalurus punctatus). The genomic DNA and cDNA encoding the channel catfish myostatin were cloned and sequenced. The myostatin gene has three exons encoding a protein of 389 amino acids. Comparison of the genomic sequences with th...

myostatin gene or growth and differentiation factor-8 inhibits the puberty and development of skeletal muscles and it could change the size of some muscles such as double muscle, if the mutation occurs. one of the most important indigenous sheep in iran, lori sheep, possess high genetic potential for meat production. therefore, the study of some genes affecting meat production would be of utmos...

Myostatin is a master regulator of myogenesis and early postnatal skeletal muscle growth. However, myostatin has been also involved in several forms of muscle wasting in adulthood, suggesting a functional role for myostatin in the regulation of skeletal muscle mass in adult. In the present study, localized ectopic expression of myostatin was achieved by gene electrotransfer of a myostatin expre...

myostatin (mstn), also known as growth and differentiation factor-8 (gdf8), is a member of the transforming growth factor beta (tgf-?) superfamily that decreases growth in mammals. a single nucleotide polymorphism (snp) in the myostatin (gdf8) 3'utr of oar2 has been known as responsible for muscular hypertrophy in foreign breeds. in this study, in order to identify single nucleotide polymo...