Immunosuppressants, particularly tacrolimus, can induce neurotoxicity in solid organ transplantation cases. A lower clinical threshold to switch from tacrolimus to another immunosuppressant agent has been a common approach to reverse this neurotoxicity. However, immunosuppressant switch may place the graft at risk, and, in some cases, continuation of the same treatment protocol may be necessary...

BACKGROUND Oxaliplatin, an effective antineoplastic agent againstgastrointestinal tumors, can cause severe peripheral neurotoxicity, which seriously limits its clinical application. To date, there are no effective treatments for this complication. Ganglioside-monosialic acid (GM1) has been shown to protect neurons against injuries and degeneration. The aim of this study was to evaluate the effe...

acrylamide (aa) is an important industrial chemical agent that is mainly used in the production of polymers and copolymers. recently it has been attention because of its production in the diet at high-temperature (>120 ºc) processes such as cooking, frying, toasting, roasting or baking of high carbohydrate foods. according to high exposure to acrylamide, recognition of its toxic effect is neces...