STUDY OBJECTIVES To assess the efficacy of ondansetron and the incidence of headache when used as prophylaxis for postoperative vomiting. DATA SOURCES Studies were identified using MEDLINE (January 1990 to July 1997) with the key words: "vomiting," "ondansetron," and "surgery" and/or "anesthesia." STUDY SELECTION All prospectively randomized trials in which ondansetron and placebo had been ...

background during abdominal surgery under regional anesthesia, nausea may happen due to several contributing factors. this study compared the effects of ondansetron and dexamethasone on nausea and vomiting under spinal anesthesia. methods one hundred and twenty patients of 15 to 35 years old with asa class i and ii were enrolled. before administering either ondansetron or dexamethasone, blood p...

introduction: patients with schizophrenia characteristically exhibit cognitive deficits. the level of cognitive impairment is found to predict the functional outcome of the illness more strongly than the severity of positive or negative symptoms. the purpose of this study was to assess the efficacy of ondansetron, a 5-ht3 receptor antagonist as an adjuvant agent in the treatment of chronic schi...

to assess the effectiveness of ondansetron pretreatment in alleviating propofol injection pain, 135 patients were randomly assigned to one of following three groups. group 1 who received up to 2 ml pretreatment 50 mg tramadol in the saline, group 2 cases who received up to 2 ml pretreatment 4 mg ondansetron in saline, and group 3 who received up to 2 ml solution saline. a 20 gauge cannula was p...

The introduction of 5-HT(3) receptor antagonist has revolutionized the prevention and treatment of nausea and vomiting in preschool aged children. These distressing symptoms, arising from multiple etiologies such as anesthesia, chemotherapy, and viral infection, are a major concern of patients and their families. Clinical research has demonstrated the antiemetic effectiveness of ondansetron in ...

AANA Journal  April 2017  Vol. 85, No. 2 113 Hypotension and bradycardia are common adverse effects following spinal anesthesia. Ondansetron has been studied in the attenuation of spinal anesthesia– induced hypotension (SIH) and bradycardia because of its antagonistic effect on the Bezold-Jarisch reflex. The purpose of this systematic review and meta-analysis of randomized controlled trials (...

BACKGROUND 5-HT(3) antagonists have been shown to be effective in relieving the symptoms of irritable bowel syndrome with diarrhoea (IBS-D). Using a recently validated magnetic resonance imaging (MRI) method, we have demonstrated reduced fasting small bowel water content (SBWC) in IBS-D associated with accelerated small bowel transit. We hypothesized that slowing of transit with ondansetron wou...

The duration of the antiemetic effect of granisetron was examined in a pilot study of patients (n = 26) undergoing a standard emetogenic stimulus in the form of total body irradiation fractionated over 3-4 days, in a randomized comparison with twice-daily ondansetron. A single intravenous dose of granisetron at the onset of therapy was effective over the entire follow-up period in 50% (6/12) of...

Background. Postoperative nausea and vomiting (PONV) is a significant complication after laparoscopic surgeries. Ondansetron and dexamethasone are most commonly used drugs for PONV prophylaxis. Comparisons of these two drugs have not been systematically reviewed till date.Methods. PubMed, PubMed Central, and CENTRAL databases were searched with the following words: “dexamethasone,” “ondansetron...