Only one of eight possible diastereomers of the organometallic chiral-at-metal complex [ZrL2(CH2Ph)2] (L = a bidentate, chiral non-racemic pyrdine alcoholate) is observed by NMR spectroscopy in the slow exchange regime.

Core alteration, affording heteroporphyrinoids and carbaporphyrinoids, allows for the exploration of porphyrin-like or porphyrin-unlike coordination chemistry. Such a strategy has provided a fundamental change in the approach to macrocyclic organometallic chemistry. The specific reactivity of porphyrinoids has offered an insight into reactions inside particularly shaped macrocyclic architecture...

Chiral, or asymmetric catalysis is the most efficient approach to chiral molecules in the enantiomerically enriched form. Organocatalysis and organometallic catalysis are nowadays the methods of choice in this field. In the first case enantiomerically pure chiral organic molecules of different symmetry classes exhibit catalytic effect, in the second one chiral organic molecule acts as the ligan...

Attaching peptides to metallodrugs may result in improved biological properties of the complexes. The potential use of cell penetrating peptides (CPPs) as cell delivery vectors is attractive, since directed cell uptake of (metallo)drugs remains a major challenge in anticancer drug design. In this work, we report the synthesis of peptide conjugates of the organometallic Os(II) anticancer complex...

The vast majority of racemic solutions of chiral compounds apparently crystallize at room temperature in non-Sohncke space groups as racemic crystals. However, kryptoracemic crystals composed of nearly enantiomeric pairs occasionally crystallize at room temperature, or appear as low-temperature phases, in Sohncke space groups. As a complement to the previously published catalog of organic krypt...

The chemistry of metal cyclopropenyl complexes derived from deprotonation of cationic ruthenium vinylidene complexes is reviewed. Such a metal coordinated cyclopropenyl ligand can be used for the preparation of heterocyclic compounds. The chemical reactivity of cyclopropenyl complexes is influenced by the nature of substituents on the three-membered ring and by the nature of ancillary ligand ar...

This article summarizes the recent developments (particularly the uses of homogeneous organometallic catalysts) in ring-opening carbonylations, ring-opening carbonylative polymerizations and ring-expansion carbonylations of heterocycles such as epoxides, aziridines, lactones and oxazolines.

Organometallic Ru(II), Os(II) and Rh(III) complexes of lapachol induce apoptosis in human tumour cell lines in the low μM range by a mode of action involving oxidative stress, especially in the case of the ruthenium compound.

From carboxylic acid trifluoromethyl aziridines, halogeno β-lactams were obtained stereoselectively by ring expansion. Different conditions such as radical, organometallic reactions allowed easy and selective access to CF3-β-lactams substituted at the C-3 position.

An apparatus has been developed for real-time monitoring of organometallic reactions under microwave irradiation using in situ Raman spectroscopy and its application for monitoring ligand substitution reactions of Mo(CO)6 demonstrated.