Aminoglycosides are broad-spectrum antibacterial agents used in the treatment of urinary tract infections, tuberculosis, visceral leishmaniasis, sepsis newborns, as well cystic fibrosis. However, use aminoglycosides is limited due to their ototoxicity — risk developing serious adverse reactions, particular, persistent irreversible hearing loss and vestibular disorders associated with death hair...

Toluene is a major industrial solvent and substance of abuse which is ototoxic in rats as shown by both behavioral testing and measurement of brainstem auditory evoked response (BAER) thresholds. The objective of this investigation was to examine the morphological (hair cell loss) and functional (BAER threshold elevations) changes resulting from toluene administration. In the preliminary experi...

Oregon Hearing Research Center, Oregon Health & Science University, Portland, OR, United States, National Center for Rehabilitative Auditory Research, VA Portland Health Care System, Portland, OR, United States, National Institute on Deafness and Other Communication Disorders, Bethesda, MD, United States, Hearing Center of Excellence, J-9, Defense Health Agency, Joint Base San Antonio, San Anto...

In view of the theory that alpha-lipoic acid effectively prevents cochlear cells from injury caused by various factors such as cisplatin and noise, this study examined whether alpha-lipoic acid can prevent kanamycin-induced ototoxicity. To this end, healthy BALB/c mice were injected subcutaneously with alpha-lipoic acid and kanamycin for 14 days. Auditory brainstem response test showed that inc...