نتایج جستجو برای: ototoxicity

تعداد نتایج: 1279  

Journal: :Journal of population therapeutics and clinical pharmacology = Journal de la therapeutique des populations et de la pharamcologie clinique 2013
Leslie Skeith Cory Yamashita Sanjay Mehta Donald Farquhar Richard B Kim

Drug-induced ototoxicity, particularly those involving phosphodiesterase type 5 (PDE-5) inhibitors, is considered to be rare and to our knowledge such an adverse effect has not been reported in Canada. Here we present a case of a 77-year old man initiated on a sildenfil regimen for the treatment of pulmonary hypertension, who developed sudden bilateral hearing loss after taking sildenafil, in t...

Journal: :JOP : Journal of the pancreas 2013
Sun Young Oh Nawal Wasif Marie Carmel Garcon Gladys Rodriguez Muhammad Wasif Saif

CONTEXT Oxaliplatin, a third-generation platinum derivative is commonly used for the treatment of colorectal cancer, pancreatic cancer, upper gastrointestinal cancer, hepatobiliary cancer, and ovarian cancer. Neurotoxicity is the dose limiting toxicity and ototoxicity is very rare, less than 1% of patients. CASE REPORT We present a case of a female patient with locally advanced unresectable p...

Journal: :Journal of rehabilitation research and development 2002
Nancy E Vaughan Stephen A Fausti Stephen Chelius David Phillips Wendy Helt James A Henry

A primary focus of research at the National Center for Rehabilitative Auditory Research (NCRAR) has been to develop methodology for rapid and efficient early detection of ototoxicity. It has been shown that an individualized, limited frequency range can be identified, which is sensitive to early ototoxic changes in the auditory system. In this study, a rapid identification protocol for identify...

2017
Nesrine Benkafadar Julien Menardo Jérôme Bourien Régis Nouvian Florence François Didier Decaudin Domenico Maiorano Jean-Luc Puel Jing Wang

Cisplatin is a widely used chemotherapy drug, despite its significant ototoxic side effects. To date, the mechanism of cisplatin-induced ototoxicity remains unclear, and hearing preservation during cisplatin-based chemotherapy in patients is lacking. We found activation of the ATM-Chk2-p53 pathway to be a major determinant of cisplatin ototoxicity. However, prevention of cisplatin-induced ototo...

Journal: :Annals of the New York Academy of Sciences 1999

Journal: :Laryngoscope Investigative Otolaryngology 2021

Journal: :AUDIOLOGY JAPAN 1972

Journal: :The Journal of Laryngology & Otology 1984

Journal: :The Journal of the Acoustical Society of America 1976

2001
Nancy D. Doolittle Leslie L. Muldoon Robert E. Brummett Rose Marie Tyson Cynthia Lacy Joseph S. Bubalo Dale F. Kraemer Michael C. Heinrich James A. Henry Edward A. Neuwelt

Carboplatin is effective in the treatment of malignant brain tumors. However, when administered in conjunction with osmotic opening of the blood-brain barrier (BBB), carboplatin is ototoxic. The purpose of this study was to determine whether delayed administration of sodium thiosulfate (STS), given after BBB closure, provided protection against carboplatin ototoxicity. Patients underwent monthl...

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