In the previous study fifteen jatrophane diterpenes were isolated from Euphorbia nicaeensis latex. Fourteen of them have been shown to be potent P-glycoprotein (P-gp) inhibitor in two MDR cancer cells (NCI-H460/R and DLD1-TxR). The aim this was determine whether which can root plant, then examine their inhibition power on selected cell lines (NCI- -H460, DLD1, U87, NCI-H460/R, DLD1-TxR U87-TxR)...

The multidrug resistance P-glycoprotein is a transmembrane efflux pump expressed by lymphocytes and is involved in their cytolytic activity. In the present study, we investigated the age-related changes of P-glycoprotein function in normal peripheral blood lymphocytes. Blood samples from 90 normal volunteers (age range, 0 to 86 years) were analyzed. P-glycoprotein function was assessed by the f...

BACKGROUND Neoadjuvant chemotherapy (NACT) is an integral part of multi-modality approach in the management of locally advanced breast cancer. It is vital to predict response to chemotherapy in order to tailor the regime for a particular patient. The prediction would help in avoiding the toxicity induced by an ineffective chemotherapeutic regime in a non-responder and would also help in the pla...

Antineoplastic agents may be very effective in the first round of combination chemotherapy; however, upon subsequent treatment, many tumours display resistance. In many instances , drug resistance is observed to multiple agents which differ in structure as well as in their mechanism of action. Development of such multidrug resistance (MDR) is a major obstacle in the treatment of a variety of ma...

P-glycoprotein is considered to be a major factor impeding effective drug therapy for many diseases of the central nervous system (CNS). Thus, efforts are being made to gain a better understanding of P-glycoprotein's role in drug distribution to brain parenchyma and cerebrospinal fluid (CSF). The goal of this study was to validate and introduce a novel P-glycoprotein-deficient (ABCB1-1Delta) ca...

Overview of the Issue P-glycoprotein, encoded by the MDR1 (also known as the ABCB1 gene) plays an important role in the absorption, distribution, metabolism and excretion of many drugs. It is not surprising, then, that dysfunction of P-glycoprotein increases susceptibility to drug toxicity (antiparasitic agents, anti-diarrheal drugs, chemotherapeutic drugs, acepromazine, butorphanol and others)...

Abstract Background This study set out to look at how naringenin affected the pharmacokinetics of ranolazine in rats. The pharmacokinetic investigation rats following oral administration with or without coadministration was successfully conducted using established technique. Animals were administered same medications for 7 days as part a multiple dosage (MDS), and amount plasma calculated on 18...

PURPOSE Adjuvant intravitreal daunomycin is frequently used for the management of proliferative vitreoretinopathy (PVR). In this study the authors examined whether daunomycin could induce multidrug resistance (MDR), mediated by the mdr-1 gene product P-glycoprotein, in the cells responsible for reproliferation in vivo and in human retinal pigment epithelial (RPE) cells in vitro. METHODS Expre...

The present study was conducted to investigate the functional and transcriptional modulation of P-glycoprotein (MDR-1) by several dietary ingredients (piperine, capsaicin, daidzein, genistein, sesamin, curcumin, taurine) in vinblastine-resistant colon carcinoma LS-180 cells (LS-180V cells). The amount of rhodamine 123 accumulated in LS-180V cells was significantly increased by capsaicin, piperi...