Although we and others have generated IRS-2 knock-out (IRS-2(-/-)) mice, significant differences were seen between the two lines of IRS-2(-/-) mice in the severity of diabetes and alterations of beta-cell mass. It has been reported that although IRS-1 and IRS-3 knock-out mice showed normal blood glucose levels, IRS-1/IRS-3 double knock-out mice exhibited marked hyperglycemia. Thus, IRS-1 and IR...

RespirologyVolume 26, Issue S3 p. 176-176 AbstractFree Access P5-50: Withdrawn First published: 19 November 2021 https://doi.org/10.1111/resp.14150_257AboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text full-text accessPlease review our Terms and Conditions of Use check box below share version article.I have read accept the Wiley O...

We give an elementary proof of a result of Katz relating invariants of linked surfaces in P4. A similar result is proved for volumes in P5. Then we try to connect the geometry of the curve D = S ∩ S′ to the properties of the linked surfaces, for example we show that if D is a complete intersection, then one of the surfaces is a complete intersection too.

On a weighted graph G, a total acquisition move transfers weight from a vertex u to a neighbor v provided that the weight on v is at least as much as the weight on u. Starting with all vertices having weight 1, the total acquisition number of G, denoted at(G), is the minimum number of vertices with positive weight after a sequence of total acquisition moves. In [D. Lampert and P. Slater, Congr....

Besides the hallmark pathology of amyloid plaques and neurofibrillary tangles, it is well documented that cyclin-dependent kinase 5 (CDK5), a critical neuronal protein kinase in nervous system development, function, and survival, when deregulated and hyperactivated induces Alzheimer's disease (AD) and amyotrophic lateral sclerosis and Parkinson's disease-like phenotypes in mice. In a recent stu...

To investigate the role of insulin receptor substrate 1 (IRS-1) and IRS-2, the two ubiquitously expressed IRS proteins, in adipocyte differentiation, we established embryonic fibroblast cells with four different genotypes, i.e., wild-type, IRS-1 deficient (IRS-1(-/-)), IRS-2 deficient (IRS-2(-/-)), and IRS-1 IRS-2 double deficient (IRS-1(-/-) IRS-2(-/-)), from mouse embryos of the corresponding...

The competitive fuzzy classifier operates on the set of four features extracted from the 3x3 neighborhood of each pixel. These features are the magnitudes of differences between that pixel and its neighboring pixels on four directions. They are input into the competitive fuzzy classifier inputs that connect to five fuzzy set membership functions that represent “white background” or one of the f...

Conventionally, in specific diseases, patients receive similar therapies; relying on a "one size fits all" approach. The discovery of P5 (Predictive, Preventive, Personalized, Participatory, and psycho-cognitive) improves personalized diagnosis, treatment, and prognosis. Considering the high prevalence, mortality rate, and complexity of cancers, there is a critical necessity to choose specific ...

soil salinity is a serious problem in south khouzestan province. this study was conducted in shawoor agricultural research station, north of the city of ahwaz, on silty-clay soil with 8 dsm-1 salinity during 2006 and 2007. a completely randomized block design arranged in split plots with three replications was used. the plots (planting methods) were: broadcasting + disk harrow (p1), broadcastin...

visualization of the original scene Figure 4.9 shows an abstract depiction of the original scene. For the purpose of task decomposition we introduce five virtual points P1, P2, P3, P4, P5, which will serve as intermediate positions of the trajectories of the robot hand (see below). Generally, these positions are represented in the coordinate system of the robot arm which is attached at the stat...