Sesquiterpene lactones (SLs) are plant-derived compounds often used in traditional medicine against inflammation and cancer. This review focuses on the chemical and biological properties of SLs that lead to enhanced anticancer and anti-inflammatory effects. The chemical properties comprise alkylating center reactivity, lipophilicity, and molecular geometry and electronic features. SLs in clinic...

Glioblastoma (GBM) is an aggressive malignancy with a high rate of tumor recurrence after treatment conventional therapies. Parthenolide (PTL), sesquiterpene lactone extracted from the herb Tanacetum parthenium or feverfew, possesses anticancer properties against wide variety solid tumors. In present study, series PTL derivatives were synthesized and screened. An inhibitor, dimethylaminoparthen...