The sodium-glucose-cotransporter-2 (SGLT2) inhibitor dapagliflozin (DAPA) induces glucosuria and osmotic diuresis via inhibition of renal glucose reabsorption. Since increased diuresis retards the progression of polycystic kidney disease (PKD), we investigated the effect of DAPA in the PCK rat model of PKD. DAPA (10 mg/kg/d) or vehicle was administered by gavage to 6 week old male PCK rats (n=9...

Caroli's disease belongs to a group of hepatic fibropolycystic diseases and is a hepatic manifestation of autosomal recessive polycystic kidney disease (ARPKD). It is a congenital disorder characterized by segmental saccular dilatations of the large intrahepatic bile duct and is frequently associated with congenital hepatic fibrosis (CHF). The most viable theory explaining its pathogenesis sugg...

Pedagogical Content Knowledge (PCK) merupakan salah satu dari empat kompetensi yang harus dikuasai oleh seorang guru. Penguasaan PCK menjadi penting karena dapat mewujudkan pembelajaran efektif bagi peserta didik. Dengan demikian, mahasiswa calon guru sebagai pendidik tentu mulai mengembangkan ini sebelum berkarier profesional. Magang Bersertifikat Kampus Merdeka program pengembangan karier dis...

In this study, we examine professional development among twelve upper secondary physics teachers who participated in a design-based research (DBR) project. The were involved developing and testing learning materials modern physics, attended workshops seminars with peers, disciplinary experts, education researchers. Through qualitative analysis of four focus group interviews, found that the had ...

Abstract The pandemic situation forces the educational system to respond a variety of issues. During pandemic, it’s essential learn more about Technological-Pedagogical-Content-Knowledge (TPACK) and how it can be incorporated into pre-service physics teacher preparation. This qualitative research collects data from ten online teaching videos offline 20 teachers. study attempts comprehend appear...

Since the emergence of computers in schools during the 1980’s, there have been considerable developments by education systems and schools to develop policies and expectations for the use of information and communication technologies (ICT) to enhance learning and teaching. These have not always translated into practice, which has resulted in a focus on the need for improvements in preservice tea...

BACKGROUND AND AIMS In polycystic liver diseases (PCLDs), increased cholangiocyte proliferation and fluid secretion are key features and cholangiocyte adenosine 3',5'-cyclic monophosphate (cAMP) is an important regulator of these processes. Thus, we assessed cAMP levels and evaluated octreotide (an analogue of somatostatin known to inhibit cAMP) in hepatic cyst growth using an in vitro model of...

Numerous studies indicate that evolutionary concepts can and should be taught at the primary school level. However, teaching evolution in is presumably not yet norm globally. At same time, educational potential of lies their applicability to many curriculum topics natural social sciences. Capitalizing on this requires broad teacher content knowledge (CK) pedagogical (PCK) about concepts. much k...