نتایج جستجو برای: phenoconversion
تعداد نتایج: 71 فیلتر نتایج به سال:
The cardiac stroma provides tensile strength binding muscle cells and serves as structural scaffolding in the presence of continuous cyclic changes in mechanical tension. The principal stromal cell types are fibroblasts, but this designation belies their diversity and topographical differentiation from organ to organ, including the heart.1 For example, skin fibroblasts and vascular smooth muscl...
Recently, a biomarker panel of 10 plasma lipids, including 8 phosphatidylcholine species, was identified that could predict phenoconversion from cognitive normal aged adults to amnestic mild cognitive impairment or Alzheimer's disease (AD) within 2-3 years with >90% accuracy. The reduced levels of these plasma phospholipids could reflect altered phospholipid metabolism in the brain and peripher...
1 Phenoconversion of CYP2C9 in epilepsy limits the predictive value of 2 CYP2C9 genotype in optimizing valproate therapy 3 4 Katalin Tóth*, Tamás Bűdi*, Ádám Kiss, Manna Temesvári, Edit Háfra, Andrea Nagy, 5 Zsuzsa Szever, Katalin Monostory 6 7 1 Research Centre for Natural Sciences, Hungarian Academy of Sciences 8 Magyar Tudósok 2, H-1117 Budapest, Hungary 9 2 2 Department of Pediatrics, Semme...
0716 Quality of Life in Idiopathic REM Sleep Behavior Disorder and Isolated REM Sleep Without Atonia
Abstract Introduction Idiopathic rapid eye movement (REM) sleep behavior disorder (iRBD) can affect quality of life (QOL) for both patient and bed partner; isolated REM without atonia (iRSWA) has been less well-studied. We aimed to investigate whether QOL changes over time in those with either iRBD or iRSWA, as well compare these one another. Additionally, we attempted demonstrate certain were ...
Purpose In recent years, several publications have demonstrated the interest and usefulness of pharmacogenetics in forensic toxicology. However, this approach remains namely focused on DNA-based phenotype, which may potentially lead to misinterpretation. Other determinants such as co-medication or physiological parameters also impact phenotype. This article aims highlight importance considering...
Plasma 24-metabolite Panel Predicts Preclinical Transition to Clinical Stages of Alzheimer’s Disease
We recently documented plasma lipid dysregulation in preclinical late-onset Alzheimer's disease (LOAD). A 10 plasma lipid panel, predicted phenoconversion and provided 90% sensitivity and 85% specificity in differentiating an at-risk group from those that would remain cognitively intact. Despite these encouraging results, low positive predictive values limit the clinical usefulness of this pane...
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