Abstract Introduction Idiopathic Rapid eye movement (REM) sleep behavior disorder is a condition that can be an early sign of alpha-synuclein-mediated neurodegenerative diseases, and the course disease vary greatly from patient to patient. It important identify patients who are at risk developing diseases in future for purpose clinical trials plan their lives accordingly. Previous research has ...

Background The ARTFL-LEFFTDS Longitudinal Frontotemporal Lobar Degeneration (ALLFTD) study is designed to characterize both sporadic and familial FTLD (f-FTLD) through annual detailed clinical, neuropsychological, biomarker, neuroimaging assessments capture disease onset trajectory in preparation for therapeutic trails FTLD. Transitions from asymptomatic mild disease, or overt, may reveal criti...

Background Metabolic dysregulation has been implicated in the pathobiology of Alzheimer’s disease (AD), including familial autosomal dominant AD (ADAD). Recent metabolic neuroimaging preclinical ADAD mutation carriers suggested that levels reactive glial marker myo-inositol increase with proximity to expected age at dementia onset. It remains unclear, however, if similar change related anticipa...

Isolated rapid eye movement sleep behavior disorder (iRBD) is a harbinger for developing clinical synucleinopathies. Magnetic resonance imaging (MRI) has been suggested as tool understanding the brain bases of iRBD and its evolution. This review systematically analyzed original full text articles on structural functional MRI in patients with video-polysomnography-confirmed according to systemat...

OBJECTIVE We measured the levels of mutant huntingtin (mtHtt) and total huntingtin (tHtt) in blood leukocytes from Prospective Huntington At-Risk Observational Study (PHAROS) subjects at 50% risk of carrying the Huntington disease mutation using a homogeneous time-resolved fluorescence (HTRF) assay to assess its potential as a biomarker. METHODS Peripheral blood mononuclear cells from consent...