objectives: toxoplasma gondii is a coccidian protozoon which forms tissue cyst in different organs of infected intermediate host. the present study was conducted to demonstrate the active form of parasite in different tissues of rat, which was experimentally infected with rh strain of toxoplasma gondii using bioassay method inmice. materials & methods: in the experimental assay, 75 rats an...

background: radiation-induced lung injury is a refractory side effect in lung cancer radiotherapy, the mechanism still remains unclear, hence an appropriate animal mode may become useful to investigate it. materials and methods: 50 female wistar rats were randomly divided into 5 groups, average 10 rats/cage: a. control group b. 3gy×10f c. 6gy×5f d. 12.5gy×1f e.15.3gy×1f. by different doses of r...

introduction: anabolic – androgenic steroids (aas) are used at high doses by athletes for improving athletic ability, muscle mass and physical appearance. unfortunately, the abuse of these agents has been significantly increased. it has been established that exercise and high doses of aas may influence the hypothalamic-pituitary-gonadal axis, which can in turn affect testicular apoptosis and ma...

background and aims: the spice zingiber officinale or ginger possesses antioxidant and neuroprotective effects. in this study we hypothesized that treatment with hydroethanolic extract of ginger (50, 100 and 200 mg/kg, p.o) would have an effect on the scopolamine-induced memory impairment in rats.methods: in this experimental study, 64 male wistar rats were divided into eight groups (8 rats in ...

wound healing has always been among important and crucial subjects in medicine. morphine dependency has also been a social and health problem in the middle east. this study was aimed to investigate the effects of morphine dependency on pro-inflammatory and fibroblast cell recruitment, as well as re-epithelialization and the revascularization processes involved in secondary intention wound heali...

background & aim: parkinson's disease (pd) can be created with loss of dopaminergic substantial nigra neurons which is widely associated with oxidative stress and reduced glutathione (gsh), as the most important and abundant thiol in tissues and one of the antioxidant defense, is one of the earliest biochemical events related to parkinson's and consumption of antioxidants has a protec...

introduction: previous studies have shown that cannabinoidergic system is involved in anxiety. however, there are controversial reports in the experimental studies. the aim of this study is to evaluate the effect of pharmacological stimulation or blocking of cb1 receptors and inhibition of endocannabinoid degradation in anxiety like behavior in elevated plus-maze (epm) test in rat. the epm is o...

introduction: it has shown that listening to mozart music can potentiate spatial tasks in human and reduce seizure attacks in epileptic patients. a few studies have reported the effects of prenatal plus postpartum exposure of mice to the mozart music on brain-drived neurotrophic factor (bdnf) in the hippocampus. here we investigated the effect of postpartum exposure to the mozart music on bdnf ...

background and objectives: previous studies have shown the antinociceptive effect of morphine in animal models, but the specific anti-pain consequence of the abuse drug in female animals is unclear. the present research showed the morphine antinociception in female wistar rats using formalin test. materials and methods: subjects were 40 female wistar rats purchased from pasteur institute of ira...

background and aims: alcohol abuse is an important concern of many societies. hippocampal neurogenesis regulates abusing drugs in a positive manner. the aim of this study was to identify factors that regulate neurogenesis in isolation period that increase preference for alcohol and salt. materials and methods: in this study sixteen rats were randomly divided into two groups: pair (social) and i...