OBJECTIVES In 1998 the World Health Organization (WHO) recommended the inclusion of Haemophilus influenza type B (Hib) conjugate vaccines in infant immunization programs, whenever in accordance with national priorities. GlaxoSmithKline Biologicals has developed a new pentavalent combined diphtheria-tetanus-whole cell pertussis-hepatitis B/Hib (DTPw-HB/Hib) vaccine containing 5 microg of polyrib...

Culture supernatants prepared from reactogenic strains of Vibrio cholerae cause a decrease in the transcellular epithelial resistance of T84 intestinal cells. This decrease correlates with the presence of hemagglutinin/protease but not with the presence of other potential accessory toxins or proteases. These data suggest a possible role for hemagglutinin/protease in reactogenicity, although oth...

BACKGROUND We investigated antibody persistence in children 1 year after 2 doses of either an AS03(B)-adjuvanted split-virion or nonadjuvanted whole-virion monovalent pandemic influenza vaccine and assessed the immunogenicity and reactogenicity of a subsequent dose of trivalent influenza vaccine (TIV). METHODS Children previously immunized at age 6 months to 12 years in the original study wer...

OBJECTIVE To compare two pediatric recombinant hepatitis B vaccines-the Engerix-B reference vaccine and the Euvax-B vaccine-in terms of immunogenicity and reactogenicity, and also to investigate their interchangeability, that is, whether a three-dose hepatitis B vaccination schedule begun with a first dose of Engerix-B could be completed with two doses of Euvax-B. METHODS This study was condu...

The ongoing COVID-19 pandemic remained a major public health concern despite large-scale deployment of vaccines. One the vaccines is CoronaVac, an inactivated vaccine. efficacy vaccine was estimated at 50.7–83.5% in clinical trials. However, real-world often differed. This study described CoronaVac post-vaccination reactogenicity and immunogenicity. Serum collected on days 0, 28, 56 84 from par...

Kimberly G. Blumenthal, MD, MSc; Lacey B. Robinson, MPH; Carlos A. Camargo Jr, DrPH; Erica S. Shenoy, PhD; Aleena Banerji, MD; Adam Landman, Paige Wickner, MPH

This paper summarized some interesting aspects related with the microbiological investigations on human leptospirosis carried out in Cuba from 1959 to 2017. The role of the Cuban national reference laboratory on Spirochetes and Brucella in the microbiological surveillance, the confirmation of epidemic outbreaks and in clinical trials related on reactogenicity, immunogenicity, efficacy and effec...

background: immunization against diphtheria, tetanus and pertussis (dtp) has long been applied in iran using whole cell vac­cine. despite the role of whole cell dtp (dtwp) vaccine in reduction of mortality as a result of disastrous diseases such as diphtheria, tetanus, and pertussis, serious local and systemic complications have been attributed to these vaccines. this study was performed to det...