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نتایج جستجو برای reperfusion injury Mesenchymal stem cells Rats

تعداد نتایج: 1231151  
Journal: :International braz j urol : official journal of the Brazilian Society of Urology 2014
Zhenyu Qiu, Dun Zhou, Dongxiao Sun,

OBJECTIVE This study aims to observe the function of umbilical cord-mesenchymal stem cells (UC-MSCs) labelled with enhanced green fluorescent protein (eGFP) in the repair of renal ischaemia-reperfusion (I/R) injury, to determine the effects on inflammatory cascade in an established rat model and to explore possible pathogenesis. MATERIALS AND METHODS Sixty rats were randomly divided into thre...

Abbas Piryaei, Arash Zaminy, Mohammad Ali Shokrgozar, Mohammad Hassan Heidari, Mohsen Noroozian, Yousef Sadeghi,

Background: Spinal cord has a limited capacity to repair therefore, medical interventions are necessary for treatment of injuries. Transplantation of Schwann cells has shown a great promising result for spinal cord injury (SCI). However, harvesting Schwann cell has been limited due to donor morbidity and limited expansion capacity. Furthermore, accessible sources such as bone marrow stem cells ...

Ali Gorji, Ali Hasani Dooghabadi, Ali Jahanbazi Jahan Abad, Arezou Es'haghabadi, Farzin Naseri, Ghazale Biglari, Mohammad Moein Shirzad, Sajad Sahab Negah,

Traumatic Brain Injury (TBI) is a major cause of death and disability worldwide. TBI can cause cognitive and memory function impairments which Current medical setting is not able to cure. In this study, we hypothesized that   mesenchymal stem cells derived from Adipose tissue  transplanted with RADA1- GGS IKVAV (GSIKVAV) can rescue cognitive function. An acute model of TBI was ca...

In the bone marrow, there are certain populations of stem cell sources with the capacity to differentiate into several different types of cells. Ideally, cell transplants would be readily obtainable, easy to expand and bank, and capable of surviving for sufficient periods of time. Bone marrow mesenchymal stem cells (BM-MSCs) possess all of these characteristics. One of the most important benefi...

2016
Xiaozhi Zhao, Xuefeng Qiu, Yanting Zhang, Shiwei Zhang, Xiaoping Gu, Hongqian Guo,

It has been shown that administration of adipose derived mesenchymal stem cells (AdMSCs) enhanced structural and functional recovery of renal ischemia-reperfusion (IR) injury. Low engraftment of stem cells, however, limits the therapeutic effects of AdMSCs. The present study was designed to enhance the therapeutic effects of AdMSCs by delivering AdMSCs in a three-dimensional (3D) aggregates for...

2016
HUSSEIN SHEASHAA, AHMED LOTFY, FATMA ELHUSSEINI, AZZA ABDEL AZIZ, AZZA BAIOMY, SAMAH AWAD, AZIZA ALSAYED, ABDEL-HADY EL-GILANY, MOHAMED-AHDY A.A. SAAD, KHALED MAHMOUD, FATEN ZAHRAN, DALIA A. SALEM, AHMED SARHAN, HASSAN ABDEL GHAFFAR, MOHAMED SOBH,

Acute kidney injury (AKI) is a complex clinical condition associated with significant morbidity and mortality and lacking effective management. Ischemia-reperfusion injury (IRI) remains one of the leading causes of AKI in native and transplanted kidneys. The aim of this study was to evaluate the efficacy of adipose-derived mesenchymal stem cells (ADSCs) in the prevention of renal IRI in rats. T...

Journal: :Annual review of medicine 2008
Benjamin D Humphreys, Joseph V Bonventre,

The potential role of mesenchymal stem cells (MSCs, also called mesenchymal stromal cells) in endogenous repair and cell-based therapies for acute kidney injury (AKI) is under intensive investigation. Preclinical studies indicate that administered MSCs both ameliorate renal injury and accelerate repair. These versatile cells home to sites of injury, where they modulate the repair process. The m...

Mohammadreza Alijani, Moosa Javdani, Rasool Rahimi Junqani,

Spinal cord injury (SCI) is a neurologic disorder that have a significant impact on quality of life, life expectancy, and economic burden. SCI leads to irreversible neuronal loss and ultimately leads to paralysis. Mesenchymal stem cells (MSCs) are a promising source for cellular therapy because they have possessed the capacity of self-renewal and differentiation to several distinct mesenchymal ...

2011
Hiroyuki Kanazawa, Yasuhiro Fujimoto, Takumi Teratani, Junji Iwasaki, Naoya Kasahara, Kouji Negishi, Tatsuaki Tsuruyama, Shinji Uemoto, Eiji Kobayashi,

BACKGROUND Ischemia-reperfusion (I/R) injury associated with living donor liver transplantation impairs liver graft regeneration. Mesenchymal stem cells (MSCs) are potential cell therapeutic targets for liver disease. In this study, we demonstrate the impact of MSCs against hepatic I/R injury and hepatectomy. METHODOLOGY/PRINCIPAL FINDINGS We used a new rat model in which major hepatectomy wi...