Manganese-Enhanced cardiac MRI (MEMRI) tracks long-term in vivo survival and restorative benefit of transplanted human Amnion-Derived Mesenchymal Stem Cells (hAMSC) after porcine ischemia-reperfusion injury Rajesh Dash, Paul J Kim, Yuka Matsuura, Xiaohu Ge, Fumiaki Ikeno, Jennifer K Lyons, Ngan F Huang, Scott Metzler, Patricia Nguyen, Shahriar Heidary, Marie-Claude Parent, Tomoaki Yamamoto, Joh...

Manganese-enhanced MRI detects live human amnion-derived mesenchymal stem cells in vivo after transplantation and restoration of myocardial function in a pig ischemia-reperfusion injury model Rajesh Dash, Ildiko Toma, Fumiaki Ikeno, Jennifer K Lyons, Shahriar Heidary, Marie-Claude Parent, INing E Wang, Xiaohu Ge, Jaehoon Chung, Justin Lam, Paul J Kim, Kaori Nakagawa, Svetlana Lyalina, Grace Do,...

BACKGROUND Although relatively uncommon, spontaneous healing from a meniscus injury has been observed even within the avascular area. This may be the result of the existence of mesenchymal stem cells in synovial fluid. QUESTIONS/PURPOSES The purpose of this study was to investigate whether mesenchymal stem cells existed in the synovial fluid of the knee after meniscus injury. METHODS Synovi...

objective: most people experience bone damage and bone disorders during their lifetimes. the use of autografts is a suitable way for injury recovery and healing. mesenchymal stem cells (mscs) are key players in tissue engineering and regenerative medicine. their proliferation potential and multipotent differentiation ability enable mscs to be considered as appropriate cells for therapy and clin...

multiple sclerosis (ms) is an autoimmune disease, which is characterized by demyelination and neuroinflammation. extracellular matrix (ecm) have important role in the central nervous system (cns). alterations are happening to the ecm after the cns disorder like ms, alzheimer and other neural injury. tenasin-c (tnc) is a glycoprotein that is highly expressed in inflammatory conditions of the cns...

naturally the brain is ineffective in regenerating functional tissue after disease or injury, so to overcome these defects innovative curative strategies such as stem cell transplantation and tissue engineering have to be considered. researchers investigate the use of strategies to attain better functional repair results. one of the important challenges of effective transplantation is the deliv...

Spinal cord injury (SCI) is one of the devastating conditions leading to functional and neurological deficits following road traffic accidents. To date, there is no definite treatment for repairing damaged spinal cord tissue. In this regard, cell therapy opens a new window in front of scientists by using different cells such as mesenchymal stem cells, olfactory ensheathing cells, Schwann cells,...

OBJECTIVE This study aims to observe the function of umbilical cord-mesenchymal stem cells (UC-MSCs) labelled with enhanced green fluorescent protein (eGFP) in the repair of renal ischaemia-reperfusion (I/R) injury, to determine the effects on inflammatory cascade in an established rat model and to explore possible pathogenesis. MATERIALS AND METHODS Sixty rats were randomly divided into thre...

Traumatic Brain Injury (TBI) is a major cause of death and disability worldwide. TBI can cause cognitive and memory function impairments which Current medical setting is not able to cure. In this study, we hypothesized that   mesenchymal stem cells derived from Adipose tissue  transplanted with RADA1- GGS IKVAV (GSIKVAV) can rescue cognitive function. An acute model of TBI was ca...

spinal cord injury (sci) is one of the devastating conditions leading to functional and neurological deficits following road traffic accidents. to date, there is no definite treatment for repairing damaged spinal cord tissue. in this regard, cell therapy opens a new window in front of scientists by using different cells such as mesenchymal stem cells, olfactory ensheathing cells, schwann cells,...