background and objectives: psychrotrophic bacteria can produce enzymes at low temperatures; this provides a wide biotechnological potential, and offers numerous economical advantages over the use of mesophilic bacteria. in this study, extracellular protease production by psychrotrophic rheinheimera sp. (km459533) was optimized by the response surface methodology. materials and methods: the cult...

This article presents an algorithm for constructing orthogonal Latin hypercubes, given a fixed sample size, in more dimensions than previous approaches. In addition, we detail a method that dramatically improves the space-filling properties of the resultant Latin hypercubes at the expense of inducing small correlations between the columns in the design matrix. Although the designs are applicabl...

Vowel Spaces within and across Language Communities Andrew R. Plummer, Lucie Ménard , Benjamin Munson, Mary E. Beckman Dept. of Linguistics, The Ohio State University, Columbus, OH, USA département de linguistique, Université du Québec à Montréal, Montréal, Canada Dept. of Speech-Language-Hearing Sciences, University of Minnesota, Minneapolis, MN, USA {plummer,mbeckman}@ling.ohio-state.edu, men...

Amine is one of candidate solvents that can be used for CO2 recovery from the flue gas by conventional chemical absorption/desorption process. In this work, we analyzed the impact of different amine absorbents and their concentrations, the absorber and stripper column heights and the operating conditions on the cost of CO2 recovery plant for post-combustion CO2 removal. For each amine solvent, ...

This paper presents results obtained from simulating a service system with process oriented simulation methodology. To make the service system responsive and efficient, the SCOR modeling idea is incorporated to build the simulation model. Awesim is a process oriented simulation modeling methodology and so is the Supply Chain Operations Reference (SCOR), developed by supply chain council. A dent...

Models for mixtures of ingredients are typically tted by Schee e's canonical model forms. An alternative representation is discussed which ooers attractive symmetries, compact notation and homogeneous model functions. It is based on the Kronecker algebra of vectors and matrices, used successfully in previous response surface work. These alternative polynomials are contrasted with those of Schee...

Many multivariate functions in engineering models vary primarily along a few directions in the space of input parameters. When these directions correspond to coordinate directions, one may apply global sensitivity measures to determine the most influential parameters. However, these methods perform poorly when the directions of variability are not aligned with the natural coordinates of the inp...

A methodology is proposed to jointly model treatments with quantitative levels measured throughout time by combining the response surface and growth curve techniques. The model parameters, which measure the effect throughout time of the factors related to the second-order response surface model, are estimated. These estimates are made through a suitable transformation that allows to express the...

We present the calibration of a mobility model for a 0.25μm CMOS technology using response surface methodology. For this process several measurements for different gate lengths (0.2μm 4.0μm) were made. Care was taken to eliminate the statistical variations typical to sub-micron devices by measuring several chips on the the same wafer and taking an average sample.