A purification procedure for rat and mouse brain histamine N-methyltransferase (HMT. EC 2.1.1.8) is described which achieves the preparation of 87-fold purified rat brain and 166-fold purified mouse brain enzyme. The purified HMT (MW 29.000) is inhibited by a number of physiologically and pharmacologically active amines. among them several methylated indoleamines. at concentrations above 5 x M....

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ARTICLES Real-time quantitative reverse transcription PCR for monitoring of blood-stage Plasmodium falciparum infections in malaria human challenge trials Sean C. Murphy, Jennifer L. Prentice, Kathryn Williamson, Carolyn K. Wallis, Ferric C. Fang, Michal Fried, Cris Pinzon, Ruobing Wang, Angela K. Talley, Stefan H. I. Kappe, Patrick E. Duffy, and Brad T. Cookson 383 Short report: Effi cacy of a...

Because of their adaptation to a diverse set of habitats and stresses, wild species of cultivated crops offer new sources of genetic diversity for germplasm improvement. Using an Infinium array representing a genome-wide set of 8303 single nucleotide polymorphisms (SNPs), phylogenetic relationships and allelic diversity were evaluated within a diversity panel of germplasm from Solanum sect. Pet...

The metallurgical performance of the column flotation process is determined by the concentrate grade and recovery. Although the former can be continuously measured using an on-stream analyzer, the latter must be estimated by a material balance calculation based on seldom verified steady-state assumptions. Consequently, the automatic control and optimization of flotation columns should be perfor...

This study draws on team adaptation theory to examine how agile behavior within Information Systems development (ISD) teams influences team performance. We conceptualize agile behavior as the degree to which ISD teams use agile practices and test a theoretical model that links agile practice use to two key components of team adaptation—shared mental models and backup behavior. Moreover, in line...

References Annemans, L., K. Caekelbergh, B. Morlion, G. Hans, C. P. De and S. Marbaix (2008). "A cost-utility analysis of pregabalin in the management of peripheral neuropathic pain." Acta Clinica Belgica 63(3): 170-178, Armstrong, E. P., D. C. Malone, B. McCarberg, C. J. Panarites and S. V. Pham (2011). "Cost-effectiveness analysis of a new 8% capsaicin patch compared to existing therapies for...

and Salas (1985) compared kriging with several other interpolation techniques, including inverse distance, for The choice of an optimal interpolation technique for estimating annual precipitation distributions and found kriging to soil properties at unsampled locations is an important issue in sitebe superior to inverse distance weighting. Warrick et specific management. The objective of this s...

OBJECTIVE To describe the Reference Centers for Special Immunobiologicals and evaluate their implementation considering formal regulations. METHODS We conducted a program evaluation, of evaluative research type. From August 2011 to January 2012, a questionnaire was applied to the 42 Reference Centers for Special Immunobiologicals existing in the Country, approaching the structure, human resou...

The habenula consists of a set of nuclei located in the epithalamus. It regulates the release of multiple neuromodulators including serotonin and dopamine, and consists of two major subdivisions— medial and lateral. In all vertebrates, the medial habenula projects to the interpeduncular nucleus (IPN), a midline structure with poorly defined functions (Morley, 1986). Both the medial habenula and...