The rat is a frequently used experimental model in studies involving human disease. We review several methods of inducing hepatic fibrosis and cirrhosis in rats. These include induction by hepatotoxins and hepatocarcinogens such as carbon tetrachloride, dimethylnitrosamine, thioacetamide and furan; the hepatoxin-cum-nutrient, alcohol; a high fat-low choline-low protein diet; immunologic agents ...

groups. Group 1 (n = 10) continued to be on food and water ad libitum and served as control. Group 2 (n = 10) received TA (0.3 g/L) of drinking water (5, 6) and food ad libitum for 16 weeks. Group 3 (n = 10) rats received TA (0.3 g/L) and sodium selenite (4 mg/L) of drinking water (7) and food ad libitum for 16 weeks. Group 4 (n = 10) received TA (0.3 g/L) of drinking water for the first 8 week...

ZnS  nanoparticles  were  synthesized  via  a  simple  surfactant  free microwave  route.  In  this  synthesis, thioacetamide  was  used  as sulfur  source.  The effects  of different  parameters  such  as  type of zinc precursor,  time  and  power  of  irradiation  on  the  morphology and  particle  size  of  the  products  have been  investigated.  The nanostructures  were  characterized  by ...

Introduction Thioredoxin (Trx) is an endogenous multifunctional protein with a redox-active disulfide/dithiol within the conserved active site sequence: -Cys-Gly-Pro-Cys[1]. Trx is also a stress-inducible protein whose expression is enhanced by various types of stresses, e.g., viral infection, exposure to UV light, x-ray irradiation, and hydrogen peroxide (H2O2) [2]. Furthermore, Trx is a scave...