Objective: To investigate the protective effects of Haeganjeon on a thioacetamide (TAA)-induced liver fibrosis mouse model and to determine Haegan-jeon signaling pathway.Methods: Mice were randomly divided into 4 groups: Normal group (Nor), TAA-induced (Con), administered 50 mg/kg silymarin (S50), 200 (H200). The was established by intraperitoneal injection with TAA three times week for 8 weeks...

BACKGROUND As a serious neuropsychiatric disease, hepatic encephalopathy (HE) is a clinical condition with several types regarding chronicity and clinical diversity that can develop as a complication of both acute and chronic liver failure. This study evaluates changes in thioacetamide (TAA)-induced acute hepatic encephalopathy (AHE) in rat as an animal model. METHODS Both genders of C57BL6, ...

Various serum proteins are synthesized in the liver. Their serum levels may reduce or elevate due to liver disorders. Thioacetamide (TAA) is a powerful hepatotoxicant, multiple protein systems have been revealed to be injured, counting those present in the mitochondrial respiration, endoplasmic reticulum, and stress response proteins. The study was conducted to evaluate the hepatoprotective pot...

In this study, it was aimed to determinate beneficial effects of Nerolidol (NLR) against reproductive toxicity caused by Thioacetamide (TAA). Male, 3-4-months-old, rats (n=32) were divided into four groups. Group-1 was kept as control and given corn oil as carrier. Group-2 received TAA (200 mg/kg, intraperitoneal (i.p.), two times per week) for 3 weeks, in group-3; NRL was orally administered a...