This study was designed to evaluate the effects of curcumin supplementation on antioxidant enzymes in thioacetamide induced cirrhotic rats. For this purpose 24 male Albino wistar rats were divided into four groups (n=6). Group I, remained healthy control rats, Group II, received thioacetamide (at a dose of 200mg/kg b.w, twice a week i.p, for 12 weeks) in first phase and saline in second phase, ...

Administration of thioacetamide to rats was found to increase the activity of liver messenger RNA in the wheat germ protein synthesis assay. The synthesis of total protein was increased about 2.5-fold after 4 days of treatment. The treatment was associated with an increase in the relative quantity of polyadenylic acid-containing RNA. Immunoprecipitation studies showed that albumin synthesis dir...

The effect of thioacetamide on dividing cells of regenerating rat liver has been studied. Rats were given daily subcutaneous injections of thioacetamide as a 1 per cent solution at a dosage of 5 mg./100 gm. body weight for 7 to 10 days, subjected to partial hepatectomy, and sacrificed 28 to 31 hours later. Thioacetamide treatment results in striking increases in the nuclear ribonucleoproteins o...

OBJECTIVES This study was conducted to determine the effect of ethanolic extract of the dried stems of Tinospora crispa in a male rat model of hepatic fibrosis caused by the hepatotoxin, thioacetamide. MATERIALS AND METHODS The extract was gavaged daily to the rats, at doses of 100 and 200 mg/kg along with thioacetamide at a dose of 200 mg/kg twice weekly. To assess the effectivity of extract...

BACKGROUND/AIMS Oxidative stress has been implicated in liver cirrhosis. Carbon tetrachloride and thioacetamide are the most widely used models to develop cirrhosis in rats and the present study compares oxidative stress in the liver induced by these compounds at different stages of cirrhosis development. METHODS Twice-weekly intragastric or intraperitoneal administration of carbon tetrachlor...

Selenium is an essential trace element and has been shown to protect the rats against dietary liver necrosis. This study was designed to evaluate the effects of selenium supplementation on different biochemical parameters in thioacetamide induced cirrhotic rats. For this purpose 24 male Albino wistar rats were divided into four groups (n=6). Group I, remained healthy control rats, Group II, rec...

Thioacetamide, adminlstered in a dose of 50/mg/kg for 9 days, produced a profound effect on the distribution and labeling of ribonucleic acid (RNA) of the rat liver. The amount of p-RNA (released by phenol into the aqueous phase) and r-RNA (which re mained in the phenol), was increased twoto threefold in the nuclei. In the nucleoli, the amount of p-RNA was doubled, and the r-RNA was increased b...

The goal of the present study was to compare the nuclear phosphoproteins of normal and thioacetamide-treated rat liver, which are nondividing tissues, with regenerating rat liver and Novikoff hepatoma, which are growing and divid ing tissues. Thioacetamide treatment was utilized to induce nucleolar hypertrophy (1, 9). With the increased resolution of the 2-dimensional elec trophoresis method, (...

Objective: Liver is an important organ that is exposed to many oxidant and carcinogenic agents, thus antioxidant compounds are beneficial for liver health. Artemisia contains flavonoid compounds and anti-diabetic, antioxidant, and anti-inflammatory properties. Due to possessing terpene and sesquiterpene compounds, this plant has antioxidant properties. This study was done to investigate the eff...

A number of studies have shown that the metabolic and proliferative properties of cells may be correlated with the size of their nucleoli (14). Generally, cells engaged in rapid protein synthesis or replication possess enlarged nucleoli. On the basis of morphological changes and autoradiographic studies, it has been suggested that the nucleolus is a site of rapid synthesis of ribonucleic acid a...