Abstract Purpose: To evaluate the efficacy of teprotumumab for treatment patients with chronic, progressive Thyroid Eye Disease (TED) who do not meet inclusion and exclusion criteria used in prior clinical trials. Methods: This is a prospective case series TED, defined as ocular symptoms more than 9 months to initiation teprotumumab, an insulin-like growth factor I receptor inhibitor (10 mg/kg ...

Abstract We expand the recent work on clustering of synthetic routes and train a deep learning model to predict distances between arbitrary routes. The is based long short-term memory representation route trained as twin network reproduce tree edit distance (TED) two machine approach approximately orders magnitude faster than TED enables many more from retrosynthesis prediction. clusters have h...

PURPOSE To assess the efficacy and safety of rituximab-mediated B-lymphocyte depletion as treatment for thyroid eye disease (TED). METHODS Prospective, open-label, interventional clinical trial evaluating 12 patients with TED and Clinical Activity Scores (CAS) (VISA [vision, inflammation, strabismus and appearance/exposure] classification) of 4 or greater followed for 1 year after rituximab (...

Mounting evidence suggests that exposure to radiofrequency electromagnetic radiation (RF-EMR) can influence learning and memory in rodents. In this study, we examined the effects of single exposure to 1.8 GHz RF-EMR for 30 min on subsequent recognition memory in mice, using the novel object recognition task (NORT). RF-EMR exposure at an intensity of >2.2 W/kg specific absorption rate (SAR) powe...

Background & objectives: Work-related illnesses account for a large number of social problems. According to occupational therapists, occupational diseases are considered as life-threatening factors for workers. The aim of this study was to measure air pollution to suspended particles and to assess the health risk of PM2.5 and PM10 exposure in the textile industry. Methods: This analytical-cros...

The proteolytic cleavage of C3 to generate C3b is the central and most important step in the activation of complement, a major component of innate immunity. The comparison of the crystal structures of C3 and C3b illustrates large conformational changes during the transition from C3 to C3b. Exposure of a reactive thio-ester group allows C3b to bind covalently to surfaces such as pathogens or apo...

the exposure to electromagnetic field emitted by mobile telephones is increasing rapidly worldwide that causes side effects, including thermal and non thermal side effects. ear proximity to electromagnetic source may lead to greater damage and side effects, including hearing loss. this study was performed to assess the chronic effect of exposure to electromagnetic field of mobile telephones on ...

A method for the design of low complexity timing error detectors (TEDs) for orthogonal and quasi-orthogonal space-time block coding (OSTBC and QOSTBC) receivers is presented. It is shown that a difference of threshold crossings timing estimate can be obtained for a two-transmit antenna OSTBC receiver in a frequencyflat Rayleigh fading environment. The S-curve of the resulting TED possesses an i...