cFLIP is required for epidermal integrity and skin inflammation silencing via protection from TNF-induced keratinocyte apoptosis. Here, we generated analyzed KO mice with additional TNF deficiency. Intriguingly, the ablation of rescued pathological phenotype characteristic weight loss increased mortality. Moreover, lack in these animals strongly reduced delayed hyperkeratosis apoptosis keratino...

Tumor necrosis factor-alpha (TNF-α) plays an important role in liver inflammation. CD40-CD40 ligand (CD40-CD40L) is a key receptor–ligand signaling pair involved the adaptive immune response and pathogenesis of autoimmune diseases. In mice, CD40 activation leads to sickness behavior syndrome (SBS) comprising weight loss, sleep disruption depression, which can be blocked by administration TNF-in...

Abstract Background Approximately one third of IBD patients show a primary non-response to anti-TNF therapy. An individualized treatment approach requires clinical predictors. Our previous study showed that LPS-stimulated TNF production can be used predict response infliximab in Crohn′s Disease patients. The expression the myeloid receptor TREM1 is also known as potential predictive marker for ...