introduction: repeated hyperglycemia play an important role in the development of atherosclerosis in diabetic patients. endothelium is the organ of the first-line defense against atherosclerosis and nitric oxide has a major role in this task. the aim of this study was to determine changes in plasma nitric oxide metabolites concentration during glucose tolerance test in type 2 diabetic rats. met...

diabetes mellitus (dm) and osteoporosis are common diseases and their prevalence increases with age. several investigations have indicated that type 1 dm has a significant relationship with bone loss, whereas in type 2 diabetes, this relationship is controversial. therefore, this study was conducted to determine the relationship between osteoporosis and type 2 dm in elderly people. this populat...

objective: arctium lappa (burdock), (a. lappa) root has hypoglycemic and antioxidative effects, and has been used for treatment of diabetes in tradition medicine. this study was conducted to evaluate the antidiabetic and hypolipidemic properties of a. lappa root extract on nicotinamide-streptozotocin (na-stz)-induced type2 diabetes in mice.materials and methods: in this investigation, 70 adult ...

background: the relationship of inflammatory cytokines with anxiety and depression has been reported, but their role in diabetic patients has not been fully elucidated. objective: we examined whether an association between prevalence of anxiety and depression in omani type-2 diabetic patients (n=30) and the levels of inflammatory markers such as il-1β, tnf-α, ifn-γ and c-reactive protein (crp) ...

conclusions compared with acarbose or metformin monotherapy, the addition of acarbose to metformin had superior antihyperglycemia efficacy and provided an efficacious and safe alternative for the treatment of type 2 diabetic rats. acarbose/metformin reduced the fasting blood glucose and glycated hemoglobin without significant changes in serum visfatin levels. background diabetes mellitus is a c...

objectives this study aimed to investigate the relation between depression and quality of life in patients with diabetes. patients and methods this is a cross sectional survey. subjects were selected from 330 eligible people referred to the only diabetes clinic in gorgan city during 6 months, using systematic random sampling. beak depression questionnaire and the brief questioner with 26 questi...

conclusions our findings showed that the genotype tt rs53576 oxtr, as well as t allele had significant differences in our population and play a protective role. therefore, it is suggested to place more interest on these oxtr in large populations and different ethnic groups. results the logistic regression analysis suggested no significant associations of oxtr single nucleotide polymorphism (snp...

conclusions: the prevalence of obesity in patients with type 2 diabetes mellitus in yemen is high with respect to the yemeni population, especially in females. objectives: we conducted this study to assess the prevalence of obesity in yemeni patients with type 2 diabetes mellitus. patients and methods: body mass index (bmi) of patients with type 2 diabetes mellitus who were 25-years-old or olde...

context since 2006 a relevant number of therapeutical algorithms for the management of type 2 diabetes have been proposed, generating a lively debate in the scientific community, particularly on the ideal timing for introduction of insulin therapy and on which drug should be preferred as add-on therapy in patients failing to metformin. at the moment, there is no real consensus. the aim of the p...

results apoptosis induced by pa in ins-1 cells was significantly resolved after liraglutide treatment. simultaneously, autophagy was enhanced with the treatment of pa and liraglutide. conclusions: liraglutide appears to protect ins-1 cells from apoptosis ffa-induced by promoting autophagy. conclusions these findings provide a novel role for glp-1 analogue in preventing or treating with t2d. obj...