نتایج جستجو برای: virulence determinants

تعداد نتایج: 142408  

Journal: :Journal of virology 2011
M R Hajimorad R-H Wen A L Eggenberger J H Hill M A Saghai Maroof

Identification of virulence determinants of viruses is of critical importance in virology. In search of such determinants, virologists traditionally utilize comparative genomics between a virulent and an avirulent virus strain and construct chimeras to map their locations. Subsequent comparison reveals sequence differences, and through analyses of site-directed mutants, key residues are identif...

Journal: :Infection and immunity 2006
Christopher D Herren Arindam Mitra Senthil Kumar Palaniyandi Adam Coleman Subbiah Elankumaran Suman Mukhopadhyay

The BarA-UvrY two-component system (TCS) in Escherichia coli is known to regulate a number of phenotypic traits. Both in vitro and in vivo assays, including the chicken embryo lethality assay, showed that this TCS regulates virulence in avian pathogenic E. coli (APEC) serotype O78:K80:H9. A number of virulence determinants, such as the abilities to adhere, invade, persist within tissues, surviv...

Journal: :Proceedings of the National Academy of Sciences of the United States of America 2014
Sandra Reuter Thomas R Connor Lars Barquist Danielle Walker Theresa Feltwell Simon R Harris Maria Fookes Miquette E Hall Nicola K Petty Thilo M Fuchs Jukka Corander Muriel Dufour Tamara Ringwood Cyril Savin Christiane Bouchier Liliane Martin Minna Miettinen Mikhail Shubin Julia M Riehm Riikka Laukkanen-Ninios Leila M Sihvonen Anja Siitonen Mikael Skurnik Juliana Pfrimer Falcão Hiroshi Fukushima Holger C Scholz Michael B Prentice Brendan W Wren Julian Parkhill Elisabeth Carniel Mark Achtman Alan McNally Nicholas R Thomson

The genus Yersinia has been used as a model system to study pathogen evolution. Using whole-genome sequencing of all Yersinia species, we delineate the gene complement of the whole genus and define patterns of virulence evolution. Multiple distinct ecological specializations appear to have split pathogenic strains from environmental, nonpathogenic lineages. This split demonstrates that contrary...

Journal: :Journal of bacteriology 1984
C Waalwijk J de Graaff D M MacLaren

The hemolysin plasmid pCW2, which enhances the virulence of Escherichia coli, has been mapped. Comparison of the region coding for hemolysin with other hemolysin determinants reveals differences that could explain differences in the ability to confer virulence.

Journal: :Indian journal of medical microbiology 2006
M Sritharan

An invading pathogen must have the ability to multiply successfully within the hostile environment of the mammalian host to establish an infection. Bacterial and other pathogens produce a range of virulence determinants required for pathogenicity, many of which are regulated by environmental factors; level of iron is one of the important factors intimately connected to the synthesis of some of ...

Journal: :Advances in clinical and experimental medicine : official organ Wroclaw Medical University 2015
Hassanain Al-Talib Nik Zuraina Balqis Kamarudin Chan Y Yean

BACKGROUND The genus Enterococcus is of increasing significance as a cause of nosocomial infections, and this trend is exacerbated by the development of antibiotic resistance. OBJECTIVES The aim of the present study was to estimate the potential virulence factors in enterococci and to ascertain their prevalence in Malaysian hospitals. MATERIAL AND METHODS The study comprised 222 enterococca...

Journal: :Infection and immunity 2002
Sharon J Peacock Catrin E Moore Anita Justice Maria Kantzanou Lisa Story Kathryn Mackie Gael O'Neill Nicholas P J Day

Most cases of severe Staphylococcus aureus disease cannot be explained by the action of a single virulence determinant, and it is likely that a number of factors act in combination during the infective process. This study examined the relationship between disease in humans and a large number of putative virulence determinants, both individually and in combination. S. aureus isolates (n = 334) f...

Journal: :Journal of Clinical Investigation 2011

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