MAOA-uVNTR variations in schizophrenia: case and control study

Abstract Background Schizophrenia, a chronic mental disorder, has been recognized as one of the heritable diseases with an increased level dopamine neurotransmitter. Monoamine oxidase A (MAOA) plays vital role in catabolism dopamine. It is mitochondrial enzyme which encoded by MAOA gene located on X chromosome. The aim this study was to detect potential biomarker order diagnose schizophrenia. Hence, association uVNTR repetitions and Schizophrenia investigated. Method Blood samples were collected from 102 schizophrenic patients (67 males 35 females), 103 volunteers health (65 38 females). Genomic DNA extracted polymorphisms examined using specific primed PCR. Results analysis indicated that genotype 3/3repetition (rep) showed highest frequency females. While 4 3.5 reps revealed frequencies among healthy controls men, respectively. There no significant statistical differences number repeats between control case individuals neither women (OR = 0.35, 95% CI 0.60–1.43 P 0.845) nor men 0.36, 0.80–1.64, 0.365). Conclusion In current study, sequence promoter not associated risk schizophrenia Iranian patients.