بررسی ارتباط فعالیت لیکن پلان و اجسام سیوات

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp; Lichen Planus is an inflammatory disorder of skin&nbsp; and mucous &nbsp;&nbsp; membrane, with approximately unknown etiology and pathogenesis. From &nbsp;&nbsp; the clinical aspect, the disease is characterized by polygonal, purple, itchy &nbsp;&nbsp; and plan papules. Pathological changes are various in dermis and &nbsp;&nbsp; epidermis. One of those, is necrotic Keratinocyte or Civatte Body that seen &nbsp;&nbsp; in lower layer of epidermis and specially in upper layer of dermis. &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp; This investigation was a three years study of clinical and histopathological &nbsp;&nbsp; characteristics of Lichen Planus and relationship between response of &nbsp;&nbsp; Civatte body (Civ-b) and activity of the disease, in Sina hospital of &nbsp;&nbsp; Hamadan city (1995-98). This study was an analytic cross sectional study, &nbsp;&nbsp; and was performed by 106 files and microscopic slides of the patients &nbsp;&nbsp; affected by Lichen Planus. &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp; In this study, results showed that 75.8% of all dermis Civatte Body are in &nbsp;&nbsp; active phase of disease and this number is 88.2% for epidermis. The &nbsp;&nbsp; correlation between number of Civatte body and disease activity was &nbsp;&nbsp; statistically established by Fisher&rsquo;s exact test (P value < 0.001). On the other &nbsp;&nbsp; hand, disease activity was also related to intensity of band from infiltration. &nbsp;&nbsp; Also results confirm that the more Civatte Body in dermis, the more &nbsp;&nbsp; epidermis Civatte Body. &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp; In this research, it was established that the more Civatte body, the more &nbsp;&nbsp; activity of Linchen planus and the decrease of Civatte Body shows &nbsp;&nbsp; decrease activity and relieve of disease.