A Case Report of a Novel Balanced Reciprocal Translocation t(2;14)(q11;q24) in a Young Woman with Two Pregnancy Losses
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Abstract:
Reciprocal chromosome translocations, especially balanced rearrangements are known to be one of the main causes of recurrent miscarriage. In this case report, we performed the clinical and cytogenetic analysis on a young couple with two pregnancy losses. Though the couple had a normal clinical study, the cytogenetic analysis revealed a balanced reciprocal translocation of t(2;14)(q11;q24) whereas the husband has a normal karyotype of 46,XY. Indeed based on the literature, this is the first report of t(2;14)(q11;q24) related to pregnancy loss. Therefore, cytogenetic tests are recommended for couples with a history of miscarriage more than twice.
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Journal title
volume 22 issue 1
pages 54- 61
publication date 2019-04
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