Effect of Artemisia absinthium on electrophysiological properties of isolated heart of rats
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Abstract:
Introduction: Treatment of supraventricular arrhythmia includes wide range of medical interventions. Herbal remedies are suitable alternatives for synthetic drugs due to their availability, minimal side effects and lower price. Pharmacological studies and traditional medical literature point to the cardiovascular effects of the Artemisia absinthium L. from Compositae family of plants. Methods: In the present study we used Langendorff model of isolated heart of rats as an experimental model to determine the effect of various concentrations of methanolic extract of A. absinthium (3×10 -11 %W/V to 4× 10 -8 %W/V) on electrophysiological properties of isolated hearts. Results: Our results showed depressant effect of A. absinthium extract on Wenchebach Cycle Length (WBCL), AV Conduction Time (AVCT), Effective and Functional Refractory Periods (ERP & FRP) of the isolated heart. Conclusion: The results indicated potential antiarrhythmic effect of A. absinthium extract in treating supraventricular tachyarrhythmia.
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Journal title
volume 10 issue None
pages 303- 311
publication date 2007-01
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