Effect of resistance training on plasma FGF-2 and Myostatin level in male Wistar rats

Authors

  • Alireza Khadivi Burojeny
  • Ebrahim Noorian
  • Hamid Rajabi
  • Mohammad Marandi
  • Shaghayegh Haghjoo
  • Zahra Khadivi Burojeny
Abstract:

The purpose of present study was to determine the effect of 8 weeks of  resistance training on serumic myostatin, and Fibroblast Growth Factor-2 (FGF-2) level in male Wistar rats. 20 adult male wistar rats(150-250gr) were randomly divided into 2 groups [control group; n=10 (C), resistance training; n=10 (R)]. Resistance training was conducted for 8 weeks (5 session/week) on a special 1 meter height ladder (divided by 26 stairs) with loading of 30٪ of body weight (suspended from the tail) in the first week and increased to 200٪ of body weight in the last week. Training includes 3 sets of 4 reps with 3 minutes rest between sets. At the end of last week blood samples were taken from the rats and myostatin, TGF-β1 and FGF-2 was measured in three groups with the ELISA kit. At the end of the study ،the plasma levels of the myostatin decreased [71/82±19/62 mg/dl (R) ver. 105/86±17/49 mg/dl(C). (p≤0/001)], but the level of FGF-2 increased significantly in resistance training group [102/462±11/135mg/dl (R) ver. 86/96±12/606 mg/dl (C) (p=0/048)]. In contrast, the serum level of TGF-β was not statistically different between the two groups [153/48±54/09 mg/dl (R).160/62±32/85 mg/dl (C). (p=0/725)]. This study shows that 8 weeks of resistance training reduces serum levels myostatin and increased serum levels of FGF-2. These two factors cause activation or non-activation of satellite cells (Muscle stem cells that control muscle hypertrophy). However the nerve - muscle agents in the first 8 weeks of resistance training have the maximum participation on strength increases, but in this research we see affect the signals of satellite cells in the first 8 weeks of resistance training can change significantly. Also, although serum levels of TGF-β1 in the exercise group was significantly different from the control group, but the overall value of the exercise group had slightly reduced.  

Upgrade to premium to download articles

Sign up to access the full text

Already have an account?login

similar resources

the effect of aqueous extract of garlic on formalin-induced pain in male rats

چکیده اثر عصاره آبی سیر بر درد ناشی از آزمون فرمالین در موش صحرایی نر به کوشش نرگس اسکندری روزبهانی زمینه و هدف: گیاه سیر از خانواده لیلیاسه و گونهallium sativum بومی آسیای میانه بوده و از دوران ،باستان تاکنون به خواص درمانی متفاوت آن مثل: کاهندگی قندخون، کلسترول خون، فشار خون، اثرات مفیدآن بر دستگاه قلبی عروقی و بیماریهای انعقادی خون، اثرات آنتی اکسیداتیو، درمان بیماریهای تنفسی وگوارشی، ا...

15 صفحه اول

Effects of Eight Weeks of Resistance Training on Muscle Myostatin Gene Expression and Insulin Resistance in Male Wistar Rats with Type 2 Diabetes

Background and Objectives: Muscular atrophy is one of the indicators of uncontrolled diabetes. The aim of the current study was to investigate effects of eight weeks of resistance training (RT) on myostatin gene expression in soleus muscles and insulin resistance in streptozotocin (STZ)-induced diabetic rats. Materials and Methods: In general, 14 Wistar male rats weighing 200–250 g and aging 8...

full text

the effect of resistance training on serum myostatin level and insulin resistance in obese-overweight men

the aim of this study was to determine the effect of resistance training for 10 weeks on muscle strength, lean body mass, serum myostatin, and insulin resistance in obese-overweight men. seventeen obsess-overweight men(age:=43.1±4.7 yr, body mass index = 29.1±2.17 kg/m2) participated in the study the subjects were randomly assigned to resistance training (n=9) and control (n=8) groups. resistan...

full text

The Effect of Eight Weeks of Resistance Training Under Hypoxia on Metabolic Parameters and Muscle Tissue Regeneration in Male Wistar Rats with Type 2 Diabetes

Background: Diabetic myopathy is one of the major problems in people with type2 diabetes that knowing its mechanisms can be helpful in controlling and preventing this disease. PAX7 and PGC-1α are two proteins involved in the renewal and metabolism of carbohydrates in skeletal muscle. The aim of this study was to evaluate the effect of 8weeks of resistance training under hypoxia on the content o...

full text

effect of listening strategy training on iranian efl learners listening comprehension and use of strategies

this study aimed to investigate the effects of listening strategy training on iranian efl learners listening comprehension and use of such strategies. this work, employing an experimental methodology, was conducted among 60 adult efl learners from a language institute in isfahan, iran, as participants. the participants, who were selected based on the results of a placement test, were assigned t...

15 صفحه اول

Effect of Eight Weeks of Resistance Training on Myostatin and Folistatin Proteins Content in Gastrocnemius Muscle Tissue of Elderly Rats

Introduction: Myostatin and follistatin proteins are key proteins in the regulation of muscle atrophy and hypertrophy. Aging and sarcopenia can lead to disruption of cellular mechanisms and the activity of these proteins. Therefore, the aim of the present study was to investigate the effect of eight weeks of resistance training on myostatin and folistatin proteins content in Gastrocnemius muscl...

full text

My Resources

Save resource for easier access later

Save to my library Already added to my library

{@ msg_add @}


Journal title

volume 16  issue 15

pages  11- 22

publication date 2019-01

By following a journal you will be notified via email when a new issue of this journal is published.

Keywords

Hosted on Doprax cloud platform doprax.com

copyright © 2015-2023