Protective effect of Biarum carduchrum extract on depression and pain in Parkinson's model induced by 6-hydroxydopamine in rats

Authors

  • Mahmoodi, Razieh
Abstract:

Parkinson is a long-term degenerative disorder of the central nervous system that mainly affects the motor system. Pain and emotional disorders due to Parkinson negatively affect the quality of the patient’s life. Biarum carduchrum is an antioxidant plant with some application in traditional medicine. The aim of this study is to evaluate the protective effects of Biarum carduchrum extract on pain and emotional disorders caused by 6-hydroxydopamine injection. Rats were randomly divided into 5 groups of 8 animals. The control group received normal saline. Parkinson's groups were subjected to the injection of 6- OHDA in the right anterior mid-brain (MFB). In third, fourth and fifth groups, rats received Biarum carduchrum extract at doses of 100, 200 and 400 mg/kg via gavage 7 days after induction of Parkinson for 14 days. On day 15th, behavioral tests including forced swimming test and tail flick were performed. Treatment of Parkinsonian rats with Biarum carduchrum extract at doses of 100, 200 and 400 mg dramatically reduced the duration of immobility time in the forced swimming test. Rats treated by Biarum carduchrum extract at doses of 100, 200 and 400 mg showed significantly increased resistance to pain compared with Parkinsonian rats. The results of this study show that the Biarum carduchrum extract improves depression and pain induced by Parkinson, which is probably related to its antioxidant effects.  

Upgrade to premium to download articles

Sign up to access the full text

Already have an account?login

similar resources

the effect of aqueous extract of garlic on formalin-induced pain in male rats

چکیده اثر عصاره آبی سیر بر درد ناشی از آزمون فرمالین در موش صحرایی نر به کوشش نرگس اسکندری روزبهانی زمینه و هدف: گیاه سیر از خانواده لیلیاسه و گونهallium sativum بومی آسیای میانه بوده و از دوران ،باستان تاکنون به خواص درمانی متفاوت آن مثل: کاهندگی قندخون، کلسترول خون، فشار خون، اثرات مفیدآن بر دستگاه قلبی عروقی و بیماریهای انعقادی خون، اثرات آنتی اکسیداتیو، درمان بیماریهای تنفسی وگوارشی، ا...

15 صفحه اول

Protective effect of chlorogenic acid in an experimental model of Parkinson’s disease induced by 6-hydroxydopamine in rats

Introdution: Parkinson's disease is the second most common neurodegenerative disease. Considering the antioxidant and neuroprotective properties of chlorogenic acid, the purpose of this study was to evaluate the neuroprotective effect of this substance in an experimental model of Parkinson's disease. Methods: In this experimental study, Wisar male rats (n = 32) were divided into 4 groups: sham...

full text

The Protective Effects of Citrus Aurantium Extract in A 6-Hydroxydopamine-Induced Model of Parkinson\'s Disease in Male Rats

Introduction: Parkinson's disease (PD) is a commonly diagnosed neurodegenerative disease among the elderly. Considering the limited symptomatic improvement associated with PD treatments, introduction of more effective agents is necessary. Citrus aurantium flower extract (CAE) is recognized as a neuroprotective and hepatoprotective agent with bioactive compounds, such as flavonoids, phenolics, a...

full text

Effect of WR-1065 on 6-hydroxydopamine-induced catalepsy and IL-6 level in rats

Objective(s): Neuroinflammation and oxidative stress play a key role in pathogenesis of Parkinson’s disease (PD). In the present study we investigated the effect of reactive oxygen species (ROS) scavenger WR-1065 on catalepsy and cerebrospinal fluid (CSF) level of interleukin 6(IL-6) and striatum superoxide dismutase (SOD) activity  in 6-hydroxydopamine (6-OHDA) induced experimental model of PD...

full text

Effects of Ferulago angulata Extract Against Oxidative Stress Induced by 6-hydroxydopamine in Rats

Background: Parkinson's disease is one of the prevalent degenerative diseases of the neural system. Oxidative stress, which has been recognized as the most important factor of Parkinson's disease, plays a main role in the death of neurons in this disease. Antioxidants have a proved role in the prevention of oxidative stress. Objective: Considering the presence of evidence regarding antioxid...

full text

The effect of Kardeh (Biarum Bovei) Hydro-alcoholic extract on pain threshold in STZ induced diabetic rats

Background & Aim: Diabetes mellitus in long-term through various means such as augmented oxidative stress is associated with disturbances such as pain and cognition in humans and laboratory animals. According to the evidence of anti-diabetic extract of Biarum Bovei (BB), Effect of oral administration of this extract was evaluated on blood glucose level and pain threshold in diabetic rats. Expe...

full text

My Resources

Save resource for easier access later

Save to my library Already added to my library

{@ msg_add @}


Journal title

volume 5  issue 4

pages  365- 371

publication date 2019-03

By following a journal you will be notified via email when a new issue of this journal is published.

Keywords

No Keywords

Hosted on Doprax cloud platform doprax.com

copyright © 2015-2023