The Effect of 8 Weeks of Concurrent Training on BDNF Values of Brain Hippocampus, Cognitive Function, Blood Glucose and Insulin in Streptozotocin-Induced Diabetic Rats

Authors

  • Koushki Jahromi, Maryam Department of Exercise Physiology, Faculty of Education and Psychology, Shiraz University, Shiraz, Iran
  • Omidi, Mohsen Department of Exercise Physiology, Faculty of Education and Psychology, Shiraz University, Shiraz, Iran
  • Rezaei, Rasoul Department of Exercise Physiology, Faculty of Education and Psychology, Shiraz University, Shiraz, Iran
  • Salesi, Mohsen Department of Exercise Physiology, Faculty of Education and Psychology, Shiraz University, Shiraz, Iran
Abstract:

Background: BDNF protein is the important neurotrophin that is involved in cognitive function. Diabetes can lead to impaired function and is a neurocognitive disorder's factor in hippocampus. Therefore, the purpose of this study was to evaluate the effect of 8 weeks of concurrent training on BDNF levels in the brain hippocampus and cognitive function of streptozotocin-induced diabetic rats. Methods: 40 of Sprague-Dawn rats were randomly divided into four groups: healthy inactive, non-healthy concurrent exercise, diabetic group without exercise, and diabetic concurrent exercise. Rats in the training groups performed concurrent training for 8 weeks. After 8 weeks, subjects' memory was assessed using a cognitive function test in a water maze. BDNF levels in the hippocampus were measured by Western blotting. One-way analysis of variance and LSD post hoc test were used to analyze the data. Findings: The present study showed that eight weeks of concurrent exercise resulted in a significant reduction in fasting blood sugar in the healthy exercise group compared to the diabetic group. A significant decrease in BDNF levels of the cerebral hippocampus was also observed in the diabetic exercise group compared to the diabetic group. In addition, the level of memory function in healthy exercise and diabetic exercise groups was significantly higher than healthy control and patient control. Conclusion: Concurrent exercise reduces BDNF hippocampus and increased cognitive function in the exercise group compared to the control group. As a result, it can be said that this type of exercise is very effective in improving the complications of type 2 diabetes.

Upgrade to premium to download articles

Sign up to access the full text

Already have an account?login

similar resources

the effect of aqueous extract of garlic on formalin-induced pain in male rats

چکیده اثر عصاره آبی سیر بر درد ناشی از آزمون فرمالین در موش صحرایی نر به کوشش نرگس اسکندری روزبهانی زمینه و هدف: گیاه سیر از خانواده لیلیاسه و گونهallium sativum بومی آسیای میانه بوده و از دوران ،باستان تاکنون به خواص درمانی متفاوت آن مثل: کاهندگی قندخون، کلسترول خون، فشار خون، اثرات مفیدآن بر دستگاه قلبی عروقی و بیماریهای انعقادی خون، اثرات آنتی اکسیداتیو، درمان بیماریهای تنفسی وگوارشی، ا...

15 صفحه اول

Formulation of Insulin Containing Niosomes and the Effect of Their Oral Administration on Blood Glucose in Streptozotocin-induced Diabetic rats

Multilamellar vesicles (noisome) of polyoxyethylene alkyl ether surfactants (Brij 52, 72, 76 and 92) were prepared using classic film hydration method. Vesicle formation ability of the surfactants was assessed in presence or absence of cholesterol. All used surfactants formed vesicles in the absence of cholesterol. Recombinant human insulin was used as a model protein drug to investigate encaps...

full text

the effect of taftan pozzolan on the compressive strength of concrete in the environmental conditions of oman sea (chabahar port)

cement is an essential ingredient in the concrete buildings. for production of cement considerable amount of fossil fuel and electrical energy is consumed. on the other hand for generating one tone of portland cement, nearly one ton of carbon dioxide is released. it shows that 7 percent of the total released carbon dioxide in the world relates to the cement industry. considering ecological issu...

the washback effect of discretepoint vs. integrative tests on the retention of content in knowledge tests

در این پایان نامه تاثیر دو نوع تست جزیی نگر و کلی نگر بر به یادسپاری محتوا ارزیابی شده که نتایج نشان دهندهکارایی تستهای کلی نگر بیشتر از سایر آزمونها است

15 صفحه اول

Effect of 8 weeks aerobic training on SRT1, CREB and BDNF genes expression in hippocampus of Wistar rats

Abstract Introduction & Objective: Exercise through BDNF induces its beneficial effects on the brain. However, its cellular mechanisms are not fully understood. Thus, the purpose of this study was to investigate the effect of 8 weeks aerobic training on mRNA expression of SIRT1, CREB and BDNF genes in hippocampus of male Wistar rats. Methods:Twelve 8-week-old rats were the subjects of this stud...

full text

My Resources

Save resource for easier access later

Save to my library Already added to my library

{@ msg_add @}


Journal title

volume 21  issue 6

pages  390- 403

publication date 2022-03

By following a journal you will be notified via email when a new issue of this journal is published.

Keywords

No Keywords

Hosted on Doprax cloud platform doprax.com

copyright © 2015-2023