The effect of eight weeks of aerobic training and coriander seed extract on oxidative stress and ATP indices of lung tissue in rats poisoned with hydrogen peroxide

Background & Aim: Aerobic activities and herbal supplements are used as a methods to control and reduce many diseases caused by oxidative stress, including lung diseases. The aim of this study was to investigate the effect of 8 weeks of aerobic training and coriander seed supplementation on some indicators of oxidative stress and ATP levels in lung tissue of male rats poisoned with hydrogen peroxide.  Methods: 42 adult male Wistar rats were randomly divided into 7 groups: control, poisoning, poisoning+ 5 mg/kg coriander extract (supplement 1), poisoning+ 10 mg/kg coriander extract (supplement 2), poisoning + exercise, poisoning+ Exercise+ Supplement 1, Poisoning+ Exercise+ Supplement 2. Interventions included 8 weeks (5 training sessions per week) running on a treadmill for 60 minutes and injecting coriander seed extract at doses of 5 and 10 mg/kg over two weeks. Tissue concentrations of ATP, MDA and PAB indices were evaluated using special kits and the data were analyzed by two-way analysis of variance at a significance level of 0.05. Results: Eight weeks of aerobic training significantly increased the concentration of ATP and significantly decreased the concentration of pulmonary PAB (P 0.05). On the other hand, only 10 mg/kg of coriander extract caused a significant increase in ATP concentration and a significant decrease in PAB in lung tissue (P<0.05). The interaction of aerobic exercise with doses of coriander seed extract also caused a significant increase in ATP concentration and a significant decrease in MDA and PAB concentration (P<0.05).  Conclusion: Despite the effect of interventions in modulating the effect of poisoning of some indicators, the greatest effect was observed during the interaction of aerobic exercise and high doses of coriander extract.