THE EFFECTS OF 4 WEEKS HIGH INTENSITY INTERVAL TRAINING ON MAMMALIAN RAPAMYCIN TARGET PROTEIN (MTOR) AND STEROL TRANSCRIPTION FACTOR REGULATORY PROTEIN-1 (SREBP1) PROTEINS CONTENT IN DIABETICS OBESE RATS ADIPOSE TISSUE

Background: Obesity and type 2 diabetes can impair the function of important cellular pathways. Activation of the mTOR pathway results in regulation of the SREBP1 protein for metabolism and regulation of adipose tissue. The aim of this study was to investigate the effect of 4 weeks of high intensity interval training on the content of mTOR and SREBP1 in adipose tissue of type 2 diabetic rats. Methods: In this experimental study, 12 to 2-month-old male Sprague-Dawley rats weighing 300 20± 20 g were selected and after being diabetic by induction of STZ and nicotine amide, randomly divided in two groups, diabetic training (6 rats) and diabetic control (6 rats). Exercise group training 4 days a week for 4 weeks according to the training HIIT; The control group had no exercise program. Independent t-test and dependent t-test were used for data analysis. Results: There was no significant change in mTOR protein content (p=0.12); But the SREBP1 protein content (p=0.001) increased significantly. The weight of control group (P=0.0001) and HIIT group (P=0.010) showed a significant increase. Blood sugar in the control group also increased significantly (P=0.0001), but HIIT mice did not show a significant change (P = 0.14). Conclusion: 4 weeks of HIIT training did not significantly change weight, blood glucose and mTOR protein content. But it did increase the SREBP1 content, so factors such as duration and intensity of training should be adjusted in order to achieve the best results when administering HIIT.