The relationship between serum 25-hydroxy vitamin D and blood pressure and quality of life in overweight and obese patients with type 2 diabetes mellitus compared with healthy subjects

Authors

  • Maryam Hashemian Department of Biology, School of Arts and Sciences, Utica College, Utica, USA
  • Neda Dolatkhah Physical Medicine and Rehabilitation Research Center, Aging Research Institute, Tabriz University of Medical Sciences, Tabriz, Iran
  • Saeed Hasanpour Faculty of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran
  • Seyed Kazem Shakouri Physical Medicine and Rehabilitation Research Center, Aging Research Institute, Tabriz University of Medical Sciences, Tabriz, Iran
Abstract:

Background: Vitamin D is one of the known lipoprotein hormones with metabolic properties. We aimed to determine the serum 25-hydroxy vitamin D concentration in overweight/obese subjects with diabetes mellitus type Ⅱ (DM Ⅱ) in association with systolic and diastolic blood pressure and quality of life compared with healthy participants. Methods: The current case-control study was carried out among 80 overweight/obese subjects with DM Ⅱ, and 77 healthy subjects matched by sex, age and body mass index (BMI). Serum 25-hydroxyvitamin D concentration was measured by ELISA method. In order to examine the quality of life, the Persian version of SF36 questionnaire was used.                    Results: There was significant difference between diabetic and healthy subjects considering serum 25-hydroxyvitamin D concentration (p-value = 0.012). Serum 25-hydroxyvitamin D concentration was inversely correlated with diastolic blood pressure (p-value = 0.02) and positively associated with physical function (p-value <0.001), social function (p-value <0.001) and general health (p-value <0.001) components of quality of life in diabetic subjects and physical health sub-scale (p-value = 0.004) in all participants. Conclusion: Serum 25-hydroxyvitamin D concentration was significantly lower in diabetic subjects in comparison with healthy controls. There was a significant reverse relationship between serum concentrations of 25-hydroxyvitamin D with diastolic blood pressure and on the other hand, a significant positive relationship with physical function, social function and general health components and physical health subscale of quality of life in participants with DM Ⅱ.

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Journal title

volume 11  issue 3

pages  5- 0

publication date 2020-05

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