The role and importance of DNA methylation in spermatogenesis process

Authors

  • Nasr- Esfahani, Mohammad Hossein Professor, Department of Animal Biotechnology, Reproductive Biomedicine Research Center, Royan Institute for Biotechnology, ACECR, Isfahan, Iran . Embryologist, Isfahan Fertility and Infertility Center, Isfahan, Iran
  • Nematollahi, Arezou MSc, Department of Animal Biotechnology, Reproductive Biomedicine Research Center, Royan Institute for Biotechnology, ACECR, Isfahan, Iran
  • Rezaeian, Atefeh MSc, Department of Animal Biotechnology, Reproductive Biomedicine Research Center, Royan Institute for Biotechnology, ACECR, Isfahan, Iran
Abstract:

Background: DNA methylation is one of the epigenetic marks that are created by de novo DNA methylation and be maintained through cell division. This process is catalyzed by DNA methyltransferases. DNA methylation establishment in germ line is important, since they have the potential to regulate gene expression in offspring and improper DNA methylation patterns in germ lines has serious consequences on development post fertilization. Dysregulation in epigenetic changes, especially sperm DNA methylation, may play an important role in the development of numerous diseases and has a negative effect on male fertility. The aim of this review study was to discuss about DNA methylation process and enzymes involved in this procedure and also the impact of environmental factors on the spermatogenesis process. Materials and methods: A search was conducted according to keywords in databases such as Scopus, PubMed and Google Scholar. Then, all articles that met the inclusion criteria, between 1975 and 2017, were examined. Results: Disorders in expression of DNA methyltransferases increase cellular oxidative stress and lifestyle can affect DNA methylation patterns during spermatogenesis and fertility potential in men. Conclusion: As sperm DNA methylation is closely related to male infertility, it is important to understand underlying DNA methylation mechanisms in order to develop therapeutic strategies

Upgrade to premium to download articles

Sign up to access the full text

Already have an account?login

similar resources

the analysis of the role of the speech acts theory in translating and dubbing hollywood films

از محوری ترین اثراتی که یک فیلم سینمایی ایجاد می کند دیالوگ هایی است که هنرپیش گان فیلم میگویند. به زعم یک فیلم ساز, یک شیوه متأثر نمودن مخاطب از اثر منظوره نیروی گفتارهای گوینده, مثل نیروی عاطفی, ترس آور, غم انگیز, هیجان انگیز و غیره, است. این مطالعه به بررسی این مسأله مبادرت کرده است که آیا نیروی فراگفتاری هنرپیش گان به مثابه ی اعمال گفتاری در پنج فیلم هالیوودی در نسخه های دوبله شده باز تولید...

15 صفحه اول

DNA Methylation and Its Role in the Development of Leukemia

Epigenetic changes play an essential role in cancer pathogenesis. It has been established by next-generation sequencing that more than 50% of the human cancers carry mutations in mechanisms involved in the organization of the chromatin and epigenetic regulations. DNA methylation is among the most common epigenetic changes in leukemia. In contrast to DNA mutations which are passively inherited f...

full text

the role of russia in transmission of energy from central asia and caucuses to european union

پس ازفروپاشی شوروی،رشد منابع نفت و گاز، آسیای میانه و قفقاز را در یک بازی ژئوپلتیکی انرژی قرار داده است. با در نظر گرفتن این منابع هیدروکربنی، این منطقه به یک میدانجنگ و رقابت تجاری برای بازی های ژئوپلتیکی قدرت های بزرگ جهانی تبدیل شده است. روسیه منطقه را به عنوان حیات خلوت خود تلقی نموده و علاقمند به حفظ حضورش می باشد تا همانند گذشته گاز طبیعی را به وسیله خط لوله مرکزی دریافت و به عنوان یک واس...

15 صفحه اول

the role of visual aids and translation in teaching vocabulary in est

the present study investigated the effect of the two vocabulary teaching techniques in est, namely the use of translation and the use of visual aids as two separate vocabulary teaching techniques. to answer the question of the study, a pretest (michigan test) was administered to the 58 randomly selected est students at khajeh nasiredin tusi university, faculty of mechanics. after the homogeneit...

15 صفحه اول

the role of thematic structure in comprehending spoken language

in fact this study is concerned with the relationship between the variation in thematice structure and the comprehension of spoken language. so the study focused on the following questions: 1. is there any relationship between thematic structure and the comprehension of spoken language? 2. which of the themes would have greated thematic force and be easier for the subjects to comprehend? accord...

15 صفحه اول

role of cultural iran in promotion of multilaieralism in central asia and caucasus

cultural iran is a scope that is more extended than the political territories of iran as a political unit. this concept means that cultural geography(mehdi moghanlo-1383-1) of iran is greater than its political geography which, according to history, has a long history extending west-east from kandahar to the euphrates and north-south from the persian gulf to the caucasus including transoxiana a...

15 صفحه اول

My Resources

Save resource for easier access later

Save to my library Already added to my library

{@ msg_add @}


Journal title

volume 31  issue None

pages  1- 13

publication date 2021-03

By following a journal you will be notified via email when a new issue of this journal is published.

Keywords

No Keywords

Hosted on Doprax cloud platform doprax.com

copyright © 2015-2023