Soheila Ajdary
Department of Immunology, Pasteur Institute of Iran, 69 Pasteur Ave., Tehran, Iran
[ 1 ] - Subcutaneous administration of a fusion protein composed of pertussis toxin and filamentous hemagglutinin from Bordetella pertussis induces mucosal and systemic immune responses
Objective(s): After decades of containment, pertussis disease, caused by Bordetella pertussis seems to be re-emerging and still remains a major cause of reported vaccine-preventable deaths worldwide. The current licensed whole-cell vaccines display reactogenicity while acellular vaccines are expensive and do not induce Th1-type immune responses that are required for optimum protection against t...
[ 2 ] - Development of monoclonal antibodies against axenic amastigotes of Leishmania infantum strain in Iran: Implication for diagnosis of Kala-azar
Objective(s): Leishmaniasis is endemic in 88 countries. Amastigote forms of Leishmania are experts at exploiting host cell processes to establish infection. Monoclonal antibodies are key reagents used in the diagnosis of infectious and non-infectious diseases. The aim of this study was to produce monoclonal antibodies against axenic amastigotes of the Leishmania infantum strain in Iran.Material...
[ 3 ] - غلظت پلاسمایی CD26 و CD30 در بیماری سالک
چکیده مقدمه: شایع‌ترین شکل لیشمانیا نوع پوستی آن یعنی سالک است که ضایعه‌ای جلدی بوده و معمولا با به جای گذاشتن جوشگاه ناخوش آیندی خودبخود بهبود می‌یابد اگر چه بندرت ممکن است بیماری به شکل غیر بهبود یابنده ظهور کند که به درمان‌های رایج نیز مقاوم خواهدبود پاسخTh1 در شکل بهبود یابنده و پاسخ Th2 در شکل غیربهبودیابنده بیماری نشان داده شده است. از طرف دیگر نشانگرهای CD26 و CD30 مولکولهائی سطحی هس...
[ 4 ] - Construction of a Novel DNA Vaccine Candidate encoding LmSTI1-PpSP42 Fusion Protein from Leishmania major and Phlebotomus papatasi against Cutaneous Leishmaniasis
Background: Cutaneous leishmaniasis (CL) is a serious public health problem in many tropical countries. The infection is caused by a protozoan parasite of Leishmania genus transmitted by Phlebotominae sandflies. In the present study, we constructed a eukaryotic expression vector to produce a fusion protein containing LmSTI1 from Leishmania major (L. major) and PpSP42 from Phlebotomus papatasi (...
[ 5 ] - A Historic Review of the Role of CD4+ T-Cell Subsets in Development of the Immune Responses against Cutaneous and Visceral Leishmaniases
The heterogeneity of CD4+ T cells has been investigated since the late 1970s, when their Th1 and Th2 subsets were coined. Later studies on the cutaneous form of the Leishmaniasis were focused on the experimental models of Leishmania major infection using the susceptible BALB/c and the resistant C57BL/6 mice. At the early 21st century, the regulatory T-cells subpopulation was introduced and its ...