Jamshid Hadjati
Department of Immunology, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran
[ 1 ] - Liver Oxidative Stress after Renal Ischemia-Reperfusion Injury is Leukocyte Dependent in Inbred Mice
Objective(s) There are some reports in recent years indicating that renal ischemia - reperfusion (IR) induces deleterious changes in remote organs such as liver. The aim of this study was to investigate whether leukocytes have a role on the induction of oxidative stress in liver after renal IR. Materials and Methods Inbred mice in IR donor group were subjected to renal IR injury. In sham donor gr…
[ 2 ] - Dendritic Cell Maturation with CpG for Tumor Immunotherapy
Background: Bacterial DNA has immunostimulatory effects on different types of immune cells such as dendritic cells (DCs). Application of DCs as a cellular adjuvant represents a promising approach in the immunotherapy of infectious disease and cancers. Objectives: To investigate the effect of tumor antigen pulsed DCs in the presence of CpG-1826 in treatment of a murine model of cancer. Methods: WE…
[ 3 ] - افزایش کارایی سلولهای دندریتیک اجزای پروتئینی در مقایسه با عصاره تام لیستریامونوسایتوژنز در ایمونوتراپی مدل تجربی تومور
مقدمه و هدف: استفاده از سلولهای دندریتیک بارگذاری شده با آنتیژنهای توموری در جایگاه یک اقدام درمانی برای مقابله با تومورها پیشنهادشدهاست. بهمنظور افزایش کارایی سلولهای دندریتیک از عواملی گوناگون، نظیر لیگاند مولکولهای TLR و فراوردههای باکتریایی استفادهمیشود. در این مطالعه از عصاره تام و اجزای پروتئینی باکتری لیستریا مونوسایتوژنز برای القای بلوغ سلولهای دندریتیک استفادهشدهاست. مواد و روش‌ها: سلوله…
[ 4 ] - Effects of Gamma Irradiation on Proliferation and IL-5 Production of Peripheral Blood Lymphocytes
Gamma irradiation is routinely used for suppression of lymphocyte function in transfusion and transplantation procedures. In recent years, some investigators focused on the effects of ionizing radiation on special aspects of lymphocyte function and considered the possibility of its clinical application for treatment of some immunological disorders. In this study, we evaluated the effects of five …
[ 5 ] - Effective Dendritic Cell-based Immunotherapeutic Vaccines for Acute Myeloid Leukemia (AML)
Acute myeloid leukemia (AML) is a type of poor prognosis hematological malignancies characterized by heterogeneous clonal expansion of myeloid progenitors. Leukemic stem cells are thought to form the majority of a cell population in minimal residual diseases (MRDs) which are resistant to current chemotherapeutic regimens and mediate disease relapse. Current therapeutic vaccine strategies have dev…
[ 6 ] - Blockade of Hypoxia: The Impact on Tumor Growth in an Experimental Tumor Model
Background: Tumor microenvironment is an active factor participating in immunoregulation, thereby preventing immunosurveillance and limiting the efficacy of anticancer therapies. Hypoxia as a major characteristic of solid tumors causes the expression of Hypoxia-Inducible Factor-1α (HIF-1α). This is a transcription factor that mediates hypoxic responses of tumor cells and involves in the expressio…
[ 7 ] - Effects of Dendritic Cell Vaccine Activated with Components of Lieshmania Major on Tumor Specific Response
Background: Dendritic cells (DCs) contribute essentially to the outset and course of immune responses. So in patients with malignancy, there have been considerable interests in use of these cells in different interventions. Objective: To evaluate the impact of Leishmania major’s components on DC maturation and their use as a therapeutic agent against tumor cells. Methods: The cancer model was ind…
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