Amir Reza Jalilian

Nuclear Science and Technology Research Institute (NSTRI), Tehran, Iran|Radioisotope Products and Radiation Technology Section, Department of Nuclear Sciences and Applications, International Atomic Energy Agency (IAEA), Vienna, Austria

[ 1 ] - Development and assessment of 153Sm-zoledronate complex as a possible bone pain palliative agent

Introduction:In this work, 153Sm-zoledronate (153Sm-ZLD) was studied using computational chemistry methods and prepared for possible use in bone pain palliation therapy. Methods: The Sm(ZLD)2.7H2O complex was synthesized and characterized in solid state using computational chemistry methods followed by 153...

[ 2 ] - Evaluation of DNA damage in a Her2+ cell line induced by an Auger-emitting immunoconjugate

Introduction: Auger electron based radioimmunotherapy (RIT) using 111In-DOTA-trastuzumab (111In-DOTA-antiHer2) feasibility was studied in vitro on a HER2/neu positive cell line, SkBr3. Methods:111In-DOTA-antiHer2 was prepared according to the optimized conditions followed by quality control tests including radioch...

[ 3 ] - An overview on Ga-68 radiopharmaceuticals for positron emission tomography applications

Gallium-68 a positron emitter radionuclide, with great impact on the nuclear medicine, has been widely used in positron emission tomography (PET) diagnosis of various malignancies in humans during more recent years especially in neuroendocrine tumors (NETs). The vast number of 68Ge/68Ga related generator productions, targeting molecule design (proteins, antibody fragments,...

[ 4 ] - Optimized production and quality control of 68Ga-DOTATATE

Introduction: Optimized production and quality control of 68Ga-DOTATATE as an efficient and preferable PET radiotracer for somatostatin receptor imaging in neuroendocrine tumors is of great interest. In this study effort has been made to present a fast, efficient, cost-effective and facile protocol for 68Ga-DOTATATE productions for clinical trials. Methods:68Ga...

[ 5 ] - Optimized preparation and evaluation of 99mTc-Streptomycin

Introduction: The endemic occurrence of new strains of tuberculosis around the globe has initiated new research on developing diagnostic radiopharmaceutical based on antibiotics. Methods:Tc-99m labeled streptomycin was prepared using freshly milked 99mTcO4- and various concentrations of streptomycin, stannous chloride at various temperatures in high yield radio...

[ 6 ] - Preclinical studies of 166Ho-chitosan for treatment of hepatocellular carcinoma

Introduction: Recently, due to the special characteristics of 166Ho and chitosan, 166Ho-chitosan complex was developed for treatment of tumors such as hepatocellular carcinoma. This complex has been lately prepared with high radiochemical purity in our lab. The preclinical studies of the complex however should be performed to evaluate the tracer concentration in target and...

[ 7 ] - Preparation of a 153Sm-5,10,15,20-tetrakis(4-methoxyphenyl) porphyrin complex as a possible therapeutic agent

Introduction: Porphyrins are interesting derivatives with low toxicity, tumor avidity and rapid wash-out suggested as potential radiopharmaceuticals in radiolabeled form. In this work we report, synthesis, radiolabeling, quality control, stability, partition coefficient determination and biodistribution studies of 153Sm-5,10,15,20-tetrakis(4-methoxyphenyl) porphyrin (153Sm-4-MPP) in ...

[ 8 ] - Radiolabeling and evaluation of two 177Lu-labeled bis-phosphonates

Introduction: Bone pain palliation therapy is a mandate in handling end-stage cancer patients. The development of new ligands with higher stability, better pharmacokinetics and lower unwanted tissue uptakes (liver and GI) is still ongoing. Methods: In this work Lu-177 labeled (3-amino-1-hydroxypropane-1,1-di-yl)-bis-(phosphonate) (177Lu-pamidronate; 177Lu-PAM ), ...

[ 9 ] - Radiosynthesis and evaluation of ytterbium-175 labeled bleomycin as therepeutic agent

Introduction: Bleomycins are DNA-binding biomolecules, which can be used as targeted therapy carriers when labeled with particle-emitters such as Yb-175. In this work the development of Yb-175 bleomycin (175Yb-BLM) has been reported. Methods: Yb-175 chloride was obtained by thermal neutron irradiation (3 × 1013 n.cm-2.s-1) of natural Yb2O<...

[ 10 ] - Radiosynthesis of 191Os-2-acetylpyridine thiosemicarbazone complex, as an in vivo therapeutic radionuclide generator

Introduction: Due to the anti-proliferative properties of platinum group-thiosemicarbazone complexes, the production of 191Os-labeled 2-acetyl pyridine 4-N-methylthiosemicarbazone (191Os-APMTS) was investigated. Methods: [191Osmium (T½= 15.4d) was produced via the 190Os(n,γ)191Os nuclear reaction using enriched target irradiated...

[ 11 ] - Production of Holmium-166 DOTMP: A promising agent for bone marrow ablation in hematologic malignancies

Intoduction: Therapeutic radiopharmaceuticals are radiolabeled molecules to deliver sufficient doses of ionizing radiation to specific disease sites such as bone metastases, brain and liver tumors and bone marrows malignancies including multiple myeloma. Among some therapeutic radiopharmaceuticals, 166Ho-1,4,7,10 -tetraazacyclo dodecane-1,4,7,10 tetraethy...

[ 12 ] - Radiosynthesis and biological evaluation of 111In-tris [8-Hydroxy-2-methylquinoline] complex as a possible imaging agent

Introduction: Due to the interesting pharmacological properties of radiolabeled metal oxine derivatives such as cell internalization, tumor avidity and antiproteosome activity, 111In-tris[8-Hydroxy-2-methylquinoline] (111In-HMQ) was developed in this study. Methods: 111In-HMQ was prepared using 111InCl3 and 8-Hydroxy-2-methylquinoline (HMQ) ...

[ 13 ] - Preparation and biodistribution study of 67Ga-gallium calcitonin

Introduction: In order to develop a radiolabeled calcitonin (CT) derivative for receptor imaging studies, CT was successively labeled with 67Ga-gallium chloride. Methods: The best results of the conjugation were obtained by the addition of 0.5 ml of a CT nasal pharmaceutical solution (1100 IU) to a glass tube pre-coated with DTPA-dianhydride (0.01 mg) at 25°C with continuous mild st...

[ 14 ] - Production, quality control and biological evaluation of 153Sm-TTHMP as a possible bone palliation agent

Introduction: Various bone palliative therapeutic agents have been developed and widely used for bone metastasis such as 153Sm-EDTMP. In this study, production, quality control and biodistribution studies of a newly developed therapeutic compound have been presented followed by imaging studies in wild-type rodents. Methods: 153Sm-TTHMP was prepared starting from 153<...

[ 15 ] - Production and quality control of 166Ho-Chitosan for therapeutic applications

Introduction: In this research, [166Ho]Holmium chitosan complex production is described in details, followed by determination of complex radiochemical purity, stability and biodistribution (after intra-articular injection) in wild-type male rats. Finally a Ho-166 based chitosan kit for ultimate radiosynovectomy as well as radiotherapy applications was developed. Methods: 166</s...

[ 16 ] - Production, quality control and imaging of 64Cu-ATSM in healthy rabbits for clinical applications

Introduction: [64Cu]diacetyl-bis(N4-methylthiosemicarbazone) ([64Cu]ATSM) is a well-established hypoxia imaging tracer with reproducible production and significant specifity. In this work the high yield production and quality control as well as imaging studies in healthy rabbits is reported. Methods: Copper-64 produced ...

[ 17 ] - Preliminary imaging studies of [61Cu]diacetyl-bis (N4-methylthiosemi-carbazone) in normal and hypoxic tumor models

Introduction: [61Cu]diacetyl-bis(N4-methylthiosemicarbazone) ([61Cu]ATSM) is a well-established hypoxia imaging tracer with simple production and significant specifity. In this work the accumulation of the tracer is studied in wild-type, necrotic and hypoxic fibrosarcoma tumors. Methods: [61Cu]ATSM was prepared u...

[ 18 ] - Development of Sm-153 chitosan for radiosynovectomy

Introduction: Developing new radiosynovectomy agents is of great importance due to the aging of human populations around the world and increasing the incidence of inflammatory diseases. In this work, Sm-153 chitosan agent was developed for the first time in our country and preparation and quality control of the compound is described. Methods: Sm-153 chloride was ob...

[ 19 ] - Production, quality control and biological evaluation of 153Sm-EDTMP in wild-type rodents

Introduction: Nowadays various bone pain palliative therapeutic agents have been developed for bone metastases. Among those, 153Sm-ethylenediamine tetramethylene phosphonic acid (153Sm-EDTMP) is the major therapeutic agent which is widely used in the world. In this study, production, quality control and biodistribution studies of this therapeut...

[ 20 ] - Evaluation of [67Ga] citrate in the detection of various microorganism infections in animal models

Introduction: Gallium-67 citrate has been known as a good infection agent in nuclear medicine for decades. In this work the value of 67Ga-citrate has been investigated in infected animal models using SPECT imaging at optimized/standardized conditions. Methods: The bacterial (Staphylococcus aureus; S.a. and Escherichia coli; E.c.) and fungal (<em...

[ 21 ] - The application of unconventional PET tracers in nuclear medicine

The production and application of PET tracers has been a unique step in the progress of nuclear medicine in last two decades. The most important PET tracers include F-18, C-11 and N-13 radioisotopes and many nuclear medicine centers throughout the globe are using them. However some new tracers are under their way to the mass administration, currently being in th...

[ 22 ] - Evaluation of radiolabeled streptokinase for thrombosis imaging

Introduction: Cardiovascular disease is the major cause of morbidity and mortality in developing and developed countries. Rapid diagnosis of the thrombosis can be an essential step in management of the stroke. Methods: In this work a recently developed radiolabeled streptokinase (STP) tracer was evaluated in an animal thrombotic model using SPECT imaging and biodis...

[ 23 ] - Biodistribution of [64Cu]pyruvaldehyde-bis (N4-methylthiosemicarbazone) complex in fibrosarcoma-bearing rats [Persian]

Introduction: 64Cu-pyruvaldehyde-bis(N4-methylthiosemicarbazone) (64Cu-PTSM)‍ is one of the most important copper radiopharmaceuticals used in clinical experiments. Methods: In this work, copper-64 (T1/2=12.33 h) production has been presented followed by the synthesis of the complexing agent, PTSM, and its structure was confirmed by common spectroscopic methods followed by radiolabeling w...

[ 24 ] - Experimental production and initial imaging of [18F]-14-Fluoro-6-thia-heptadecanoic acid ([18F]-FTHA) for myocardial performance [Persian]

Introduction: [18F]-6-thia-14-fluoro-heptadecanoic acid 3b, a free fatty acid, has been used in myocardial PET imaging. In order to establish an automated synthesis module for routine production in the country, a study performed for optimization of the production conditions as well as making modifications. Methods: [18F] Benzyl-14-Fluoro-6-thia-heptadecanoate 2b was prepared in no-carrier...

[ 25 ] - Preparation of [111In]-Bleomycin radiopharmaceutical [Persian]

In this study, the preparation of 111In-Bleomycin complex was optimized for temperature, time, concentration and pH during several experiments. The results showed that by the addition of bleomycin to 111In-InCl3 sample (dried under flow of N2) and heating the mixture up to 90-100°C the radiopharmaceutical can be obtained in 99.5% yield and a specific activity of 1.745 Ci/mmol. The final s...

[ 26 ] - Production, formulation and quality control of [13N]NH3 compound for PET imaging of regional blood flow [Persian]

In this study, 16O(p,α)13N nuclear reaction was chosen as the best method of N-13 production. High purity natural water targets were bombarded by 18 MeV protons with an intensity of 8μA. A production yield of 13.5 mCi/μAh was obtained. Chemical modification of 13N-nitrogen oxides into [13N]NH3 was accomplished using De Varda's catalyst. Chemical, radiochemical and radionuclide purity cont...

[ 27 ] - Tissue uptakes of 67Ga-bleomycin and carrier free 67Ga in fibrosarcoma-bearing mice

67Gallium-bleomycin complex (67Ga-BLM) was prepared using Thakour method. Radio-thin-layer-chromatography of prepared complex showed A2 and B2 radiopeaks with Rf at 0.7 and 0.4 respectively with a purity of above % 95. Tissue uptake of 67Ga-BLM and 67GaCl3 in twelve tissues including tumor, blood, liver, lung, spleen, muscle, skin, heart, kidney, colon, colon content ,bladder and the tota...

[ 28 ] - Production, formulation, quality control and primary biological studies of [18F]KF for skeletal PET scanning [Persian]

[18F]KF, considered as a reference standard for positron emission tomography of the skeletal system, was produced by the bombardment of enriched water ([18O]H2O>95%) with high energy protons in NRCAM cyclotron. After the extraction of fluoride from enriched water as KF, and passing it through microbial filter and fine adjustment of acidity and osmolality, it was converted into an injectab...

[ 29 ] - Production and quality control of 82mRb and primary PET scans using its radiopharmaceutical for heart examinations [Persian]

According to the importance of positron emitters in nuclear medicine, 82mRb was produced as a member of this group of radiopharmaceuticals. After being converted into an injectable form, enough information was provided for imaging with this radiopharmaceutical. 82mRb with high radioisotopic purity and half-life of 6.5 hours, in chloride form, can be considered as a suitable positron emitt...

[ 30 ] - Production and quality control of [18F]-FDG in Iran [Persian]

The use of [18F]-2-FDG has been increasing in recent years. This agent was originally used for evaluation of CNS glucose uptake and pathologic conditions by positron emission tomography (PET). In view of increasing demand for this agent, its production has been started at cyclotron dept., Nuclear research center for agriculture & Medicine-Karaj Iran (NRCAM). In this paper, [18F]-FDG synth...

[ 31 ] - Preclinical evaluation of 68Ga-MAA from commercial available 99mTc-MAA kit

99mTc-Macroaggregated Albumin (99mTc-MAA) has been used as a perfusion agent. This study described development of the 68Ga-MAA via commercially available kits from Pars-Isotopes Company as a 99mTc-MAA kit. 68Ge/68Ga generator was eluted with suprapure HCl (0.6 M, 6 mL) in 0.5 mL fractions. The two fractions with the highest 68GaCl3 activity were generally used for labeling purposes. After label...

[ 32 ] - Development of Ga-67 Maltolate Complex as an Imaging Agent

Due to the antitumor activity of Gallium MAL complex, as well as recent findings on new targeted biomolecules in malignant cells through this complex, the development of radiolabeled gallium complex for future imaging studies was targeted. Ga-67 labeled 3-hydroxy-2-methyl-4H-pyran-4-onate (Ga-67 MAL) was prepared using freshly prepared Ga-67 chloride and 3-hydroxy-2-methyl-4H-pyran-4-onate in a...