بختیاری, سالار
گروه بیوشیمی، دانشکده پزشکی، دانشگاه علوم پزشکی ایلام، ایلام، ایران
[ 1 ] - تعیین میزان بهبود لوکوموتور خودبخودی در موش های صحرایی با ضایعه نخاعی مزمن
Introduction: Spinal cord injury (SCI) is a serious clinical disorder, which involves the patient’s family as well as the community. After sever SCI, astrocytes of the central nervous system become reactive astrocytes, and produce glial scar which is a major obstacle to axons regeneration in the spinal cord. However, some studies have confirmed a spontaneous partial locomotor recovery in injured …
[ 2 ] - بررسی اثرات رزیگلیتازون و اپی‌گالوکاتچین‌گالات بر بیان پروتئین PGC-1α در رده سلول‌های عضلانی C2C12 مقاوم به انسولین القا شده با پالمیتات
Introduction: Alterations in lipids metabolism are one of the important mechanisms for the treatment of insulin resistance and, hence for type 2 diabetes. On the other hand, PGC-1 supportFields]> QUOTE α supportFields]>, as a key regulator of mitochondrial biogenesis and function, by increasing β-oxidation of lipids plays an important role in improving insulin sensitivity. In the present study, t…
[ 3 ] - Functional recovery assessment of spinal cord contusion model in male rats without therapeutic interventions
Introduction: Spinal cord injury (SCI) is one of the most serious clinical diseases, which not only affects the patient's physical and mental status, but its effects will be spread to family and community. After severe spinal cord injury, astrocytes of the central nervous system (CNS) become reactive astrocytes, and play the main role of glial scar formation. The scar is a major obstacle to regen…
[ 4 ] - Investigating antimicrobial activity of hydroalcoholic extract and essential oil of Tymbra spicata against some pathogenic bacteria
Introduction: Thymbra spicata (T. spicata) is a conventional medicinal herb which is commonly used in the folklore medicine system of Iran. Aim of the study was to assess the antibacterial activity of the essential oil and hudroalcholic extract of the plant T. spicata on some important bacteria. Materials & methods: The essential oil and extract of T. spicata were obtained by hydrodistillation an…
[ 5 ] - اثرات عصاره هیدروالکلی گیاه تیمبرا بر باکتری‌های گرم مثبت و منفی بیماری‌زا
مقدمه: درمان بیماری‌های باکتریایی توسط آنتی بیوتیک‌های سنتتیک با بروز مشکلاتی از قبیل ایجاد عوارض جانبی در انسان‌ها و ایجاد مقاومت در میکروارگانیسم‌ها همراه است. اخیراً به استعمال گیاهان در درمان بیماری‌های باکتریایی توجه زیادی شده است. از آنجایی که استفاد از گیاه تیمبرا اسپیکاتا در طب سنتی ایران مرسوم است، در این تحقیق اثر ضد باکتریایی عصاره این گیاه بر روی تعدادی از باکتری های بیماری‌زا بررسی شد…
[ 6 ] - بررسی فعالیت ضد باکتریایی عصاره هیدروالکلی خرزهره (Nerium oleander)
مقدمه: در طب باستانی اعراب و چین از گیاه خرزهره برای درمان بیماری‌ها استفاده می‌شود. در این تحقیق خواص ضد باکتریایی عصاره هیدروالکلی خرزهره بومی ایلام بر روی باکتری‌های بیماری‌زا مورد بررسی قرار گرفت. بحث و نتیجه‌گیری: نتایج به دست آمده نشان می‌دهد که باکتری‌های گرم مثبت نسبت به عصاره خرزهره حساس‌تر از باکتری‌های گرم منفی می‌باشند. و با توجه به قطرهاله‌های عدم رشد باکتری‌ها می‌توان عنوان کرد که ع…
[ 7 ] - Trehalose Neuroprotective Effects on the Substantia Nigra Dopaminergic Cells by Activating Autophagy and Non-canonical Nrf2 Pathways
Trehalose, as a natural disaccharide, is known as an autophagy inducer. The neuroprotectiveeffects of trehalose in the rat model of Parkinson′s disease were the aim of the present study.Parkinson′s disease model was induced by injecting 6-hydroxydopamine (6-OHDA) in thestriatum of male Wistar rats. Apomorphine-induced behavior and substantia nigra neuronalcounts were appli…
[ 8 ] - Trehalose Neuroprotective Effects on the Substantia Nigra Dopaminergic Cells by Activating Autophagy and Non-canonical Nrf2 Pathways
Trehalose, as a natural disaccharide, is known as an autophagy inducer. The neuroprotectiveeffects of trehalose in the rat model of Parkinson′s disease were the aim of the present study.Parkinson′s disease model was induced by injecting 6-hydroxydopamine (6-OHDA) in thestriatum of male Wistar rats. Apomorphine-induced behavior and substantia nigra neuronalcounts were appli…
[ 9 ] - Evaluation of Chondroitin Sulfate and Dermatan Sulfate Expression in Glial Scar to Determine Appropriate Time of Therapeutic Interventions in Contused Rats
Introduction: The proteoglycans of the extracellular matrix increases in the glial scar during spinal cord injury and significantly affects the inhibition of axonal regeneration. Methods: The results of injury therapies are limited due to the lack of identifying a timely therapeutic intervention. The present study aimed to investigate the glial scar Chondroitin Sulfate (CS) and Dermatan Sulfate…