محجوبی, فروزنده
گروه ژنتیک پزشکی، پژوهشگاه ملی مهندسی ژنتیک و زیست فناوری، تهران، ایران
[ 1 ] - بررسی بیان نسبی ژن BIF-1 در تومور سرطان پستان و بافتهای نرمال مجاور با استفاده از Real Time PCR
Introduction: Breast cancer is a complex disease due to several biological Levels of genetic and epigenetic changes that ultimately alter the cellular processes including proliferation, apoptosis, angiogenesis and the acquisition of an invasive phenotype results. BIF-1 (BAX interacting factor) is a tumor suppressor gene which is involved in the regulation of mitochondrial membrane bends and conta…
[ 2 ] - RNAi Induced Inhibition of MRP1 Expression and Reversal of Drug Resistance in Human Promyelocytic HL60 Cell Line
Multidrug resistance (MDR) is a complex phenomenon in which many different genes regulating drug transport, cellular repair, detoxification and drug metabolism are involved. Nevertheless, in most drug resistant cell lines and cancer patients up-regulation of ABC-transporter genes such as MDR associated Protein (MRP1) gene could be at the basis of the drug resistance phenotype. We aimed to decreas…
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