خضری, شیوا
استادیار، گروه زیست شناسی، دانشکده علوم دانشگاه ارومیه، ارومیه، ایران
[ 1 ] - تاثیر فنی توئین بر پلاریزه شدن پاسخ های ایمنی در آنسفالومیلیت تجربی خود ایمن (EAE)
Background and purpose: Experimental autoimmune encephalomyelitis (EAE) is an animal model of multiple sclerosis. The hallmark of this disease is an autoimmune neuroinflammation induced by autoreactive lymphocytes attack. Pervious documents indicated that phenytoin can protect axonal loss in EAE. Here, we investigated the immunomodulatory effects of phenytoin in EAE. Materials and methods: I...
[ 2 ] - بررسی مولکولی اثر پروژسترون بر کیاسمای بینایی موش صحرایی نر پس از القای دمیلیناسیون با اتیدیوم بروماید
Background and purpose: Optic neuritis is one of the appearances of Multiple Sclerosis (MS). Progesterone has a protective effect in central nervous system, so, in this study we aimed at investigating the effect of progesterone on myelin repair of the optic chiasm in male rats by studying the genes expression of Olig 2 (marker of oligodendrocyte precursor cells), GFAP (marker of astrocyte...
[ 3 ] - مطالعه حافظه کاری و مرجع فضایی در مدل تجربی بیماری مالتیپل اسکلروزیس پس از درمان با ویتامین D3
Background: The hippocampus, a vital center for learning and memory, is extremely vulnerable to neurological diseases.Several reports of cognitive and memory impairment have been published in patients with Multiple sclerosis (MS). The prevalence of MS is highest where environmental supply of vitamin D is low. In the present study spatial working memory and reference memory after treatment with ...
[ 4 ] - اثر حفاظتی تستوسترون بر بهبود نقایص شناختی القا شده توسط اتیدیوم بروماید در مدل حیوانی مالتیپل اسکلروزیس
Background: Multiple Sclerosis (MS) is a neurodegenerative disease of the central nervous system (CNS). The hippocampus is a vital center for learning and memory it is extremely vulnerable to neurodegenerative diseases. The male hormones could be neuroprotective for the CNS. The current study is an attempt to investigate the effect of testosterone on learning and spatial memory following the de...
[ 5 ] - The protective role of glycyrrhizin on ethanol- damaged B92 glial cells in vitro
Background and Purpose: Glycyrrhizin is one of the most important pharmacological compounds of the Licorice plant. The purpose of this study was to investigate the protective effects of glycyrrhizin on the B92 glial cells after treatment with ethanol. Materials and Methods: B92 cells were obtained from the Pasteur institute cell bank of Iran, (1×106 cell/ml) were transferred to 96 plates and in...
[ 6 ] - Effects of Quercetin on Improving the Damage Caused by Free Radicals in the Rat Models of Multiple Sclerosis
Background: Medicinal herbs have been used for managing various diseases for many years. Quercetin is a member of flavonoid family with antioxidant and anti-inflammatory properties. This study aimed to investigate the beneficial potential of quercetin in ameliorating experimental autoimmune encephalomyelitis (EAE). Materials and Methods: In this experimental study, EAE was induced in male Wist...
[ 7 ] - Protective Effect of Wheat Germ Oil on Sex Hormones Disorders and Uterine Tissue Disorders Morphology Following Treatment with Carbamazepine in Epileptic Female Mice with Pentylenetetrazol
Background & Objective: Epilepsy is one of the common neurological diseases and carbamazepine is an antiepileptic drug that causes oxidative stress, endocrine and the reproductive system long term disorders. The aim of this study is to evaluate the effect of wheat germ oil, as a rich source of antioxidants on sex hormones and uterine tissue in epileptic mice treated with carbamazepine. Materi...
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