هدایتی, محمد تقی
استاد، گروه قارچ شناسی پزشکی، مرکز تحقیقات قارج های تهاجمی، دانشکده پزشکی، دانشگاه علوم پزشکی مازندران، ساری، ایران
[ 1 ] - ارزیابی حساسیت دارویی وریکونازول و ایتراکونازول نسبت به 90 ایزوله محیطی و بالینی آسپرژیلوس فلاووس
Background and purpose: Invasive aspergillosis (IA) is a leading cause of morbidity and mortality in patients with decreased immune status. Aspergillus flavus is the second most common species causing invasive aspergillosis after A. fumigatus. According to limited information on the antifungal susceptibility test against A. flavus in Iran, in this study we aimed at evaluating the antifungal sus...
[ 2 ] - بررسی تنوع قارچی هوا و فیلترهای سیستم های تهویه مطبوع دانشکده های دانشگاه علوم پزشکی مازندران در سال 1393
Background and purpose: Biological pollution in indoor air is mostly created through bacteria and fungi which are harmful to human health. In the present study we evaluated the fungal diversity of air and air-conditioning systems in different schools of Mazandaran University of Medical Sciences. Materials and methods: The samples were collected from some rooms in different schools of Mazanda...
[ 3 ] - شناسایی گونه های کاندیدا از افراد دیابتی با استفاده از روش PCR-RFLP
Abstract Background and purpose: Diabetes affects the function of many organs in the body. It predisposes an environment for colonization of different microorganisms including Candida species which are normal floral of the skin, vagina and digestive system and increases their susceptibility to fungal infections. This study aimed at isolating different species of candida in diabetic patients ...
[ 4 ] - مروری بر ارتباط آلرژن های قارچی با آلرژی و بیماری های تنفسی
For years, fungi have been associated with asthma and other reactive airway diseases. In contrast to type I-mediated allergies caused by pollen, fungi cause many allergic diseases such as rhinitis, allergic bronchopulmonary mycoses, hypersensitivity pneumonitis and allergic sinusitis. Aspergillus fumigatus is the most prevalent fungi which causes severe pulmonary allergic diseases, including al...
[ 5 ] - ارزیابی بیماران مبتلا به توبرکلوزیس ریوی از نظر کلونیزاسیون قارچی و اختصاصی سرمی علیه آسپرژیلوس فومیگاتوس G ایمنوگلوبین
Background and purpose: Aspergillus is a ubiquitous fungus, which causes a wide spectrum of infections including invasive pulmonary aspergillosis (IPA), depending on the patient’s immune status and underlying lung disease. Among the Aspergillus spp, A. fumigatus remains the predominant agent of IPA. In patients with a preexisting lung cavity from a variety of causes, such as pulmonary tuberc...
[ 6 ] - In vitro antitumor activity of patulin on cervical and colorectal cancer cell lines
Background and Purpose: Patulin is a mycotoxin produced by some molds,especially Aspergillus and Penicilium, and is responsible for mycotoxicosis in animals and humans.There is still not very detailed data about the anti-cancer potency of patulin, but some reports demonstrated that it induces cellular apoptosis and toxicity. Materials and Methods: To determine the efficacy of patulin as a ther...
[ 7 ] - Hyphal wall protein 1 gene: A potential marker for the identification of different Candida species and phylogenetic analysis
Background and Purpose: Hyphal wall protein 1 (HWP1) is an important adhesin which usually is expressed on the germ tube and hyphal surface produced by different Candida species. The hyphal wall protein-coding gene (HWP1) was evaluated as a novel identification and phylogenetic marker in Candida tropicalis, C. orthopsilosis, C. parapsilosis and C. glabrata. Materials and Methods: Initially, fo...
[ 8 ] - Aspergillus species in indoor environments and their possible occupational and public health hazards
Abstract The genus Aspergillus, which consists of a few hundred opportunistic mold species found in various climatic conditions, causes diseases including localized infections, fatal diseases, allergic responses, and inhaled conidia in humans. Herein, we present an overview of the most common diseases and allergic infections caused by Aspergillus species and their associated health hazards ...
[ 9 ] - Serum immunoglobulin E and immunoglobulin G reactivity to Agaricus bisporus proteins in mushroom cultivation workers
Background and Purpose: Although molds are regarded as the main fungal allergen sources, evidence indicates that spores of Basidiomycota including Agaricus bisporus (A. bisporus) can be also found at high concentrations in the environment and may cause as many respiratory allergies as molds. The aim of the present study was to evaluate specific immunoglobulin E (IgE) and immunoglobulin G (IgG) ...
[ 10 ] - Detection of galactomannan in bronchoalveolar lavage of the intensive care unit patients at risk for invasive aspergillosis
Background and Purpose: Invasive aspergillosis (IA) is one of the most common life-threatening fungal infections among the critically ill patients including intensive care unit (ICU) patients. Delayed diagnosis and therapy may lead to poor outcomes. Diagnosis may be facilitated by a test for molecular biomarkers, i.e. detection of galactomannan (GM) antigen based on enzyme immunoassay, which is...
[ 11 ] - A real time PCR assay on blood for diagnosis of invasive candidiasis in immunocompromised patient
Background and Purpose: Invasive candidiasis (IC) is a significant cause of morbidity and mortality in patients with hematologic disorders and bone marrow transplant recipients. Rapid, specific and sensitive test for the timely accuracy in immunocompromised patients to reduce mortality rates and prevent IC progress is necessary. We established a real-time PCR assay on blood for the diagnosis an...
[ 12 ] - Prevalence of specific immunoglobulin E and G against Aspergillus fumigatus in patients with asthma
Background and Purpose: Aspergillus fumigatus as a ubiquitous fungus can be found in the respiratory tract of the asthmatic and healthy people. The inhalation of Aspergillus spores leads to an immune response in individuals with asthma and results in the aggravation of the clinical symptoms. The present study aimed to investigate the prevalence of specific immunoglobulin E and G (IgE and IgG) a...
[ 13 ] - In vitro interactions of crocin with fluconazole against Candida isolates
Background and Purpose: The incidence of invasive fungal infections has been increased in recent years. The growing use of azole drugs for prophylactic and therapeutic purposes has resulted in the gradual emergence of azole-resistant species. Accordingly, the introduction of a new strategy to improve the management of Candida infections is an urgent need. Regarding this, the present study was p...
[ 14 ] - Glabridin triggers over-expression of apoptosis inducing factor (AIF) gene in Candida albicans
Background and Purpose: Candida albicans is a prevalent human fungal pathogen that can cause a wide spectrum of diseases, from superficial mucosal infections to systemic disorders, in patients with impaired immunity. Glabridin is a pyranoisoflavan originally extracted from root extract of Glycyrrhiza glabra. Glabridin can also mediate apoptosis in yeast cells by changing the mitochondrial membr...
[ 15 ] - Invasive Aspergillosis in COVID-19: A Review Study and Recommendations for Diagnostic Approaches
Background and purpose: COVID-19 is an emerging viral disease caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Bacterial or fungal superinfections of the lung may cause complications in clinical manifestations, treatment, and increase the mortality rate. In this article, we reviewed previous studies on invasive aspergillosis (IA) in viral infections and in adjustment with...
[ 16 ] - Pediatric Catheters Infectivity and Identification of Candida Species Isolated from Hospitalized Patients in Mashhad Pediatric Hospital
Background and purpose: Invasive candidiasis in infants has high mortality rate and is often associated with colonization on medical devices such as catheters. Candida colonization is considered as a predisposing factor for Candida related infection. The aim of this study was to evaluate the rate of catheters infectivity by Candida species. Materials and methods: In this descriptive cross-sect...
[ 17 ] - Mucormycosis: A Lethal Phenomenon in COVID-19 Patients: A Review of Diagnostic and Therapeutic Approaches
Coronavirus disease 2019 (COVID-19) has seriously spread worldwide. One of the problems of COVID-19 patients is co-infection with other microbial infections such as fungal infections that are severely life-threatening. Mucormycosis, one of these opportunistic fungal diseases that is mistakenly known as black fungal disease, has been reported in Iran and the world. This non-systematic review is ...
Co-Authors