Davood Beiki

[ 1 ] - The Value of Technetium-99m Labeled Alpha-Melanocyte- Stimulating Hormone (99mTc-α-MSH) in Diagnosis of Primary and Metastatic Lesions of Malignant Melanoma

Objective(s): Malignant melanoma is the most lethal type of skin cancers with unfavorable prognosis. Alpha-MSH peptide analogues have a high affinity for melanocortine-1 (MC1) receptors on melanocytes overexpressing in malignant melanoma cells. Pre-clinical studies have shown promising results for radiolabeled MSH imaging in this malignancy. The purpose of this study is to assess the diagnostic...

[ 2 ] - Radiation-induced myocardial perfusion abnormalities in breast cancer patients following external beam radiation therapy

Objective(s): Radiation therapy for breast cancer can induce myocardial capillary injury and increase cardiovascular morbidity and mortality. A prospective cohort was conducted to study the prevalence of myocardial perfusion abnormalities following radiation therapy of left-sided breast cancer patients as compared to those with right–sided cancer. Methods: To minimize potential confounding fact...

[ 3 ] - Benefits of combined pharmacologic and submaximal exercise stress on Sub-diaphragmatic activity in myocardial perfusion scintigraphy

Introduction: Myocardial perfusion imaging (MPI) is an important imaging modality in managing patients with cardiovascular disease. MPI has a significant role in diagnosis and management of cardiovascular disease; however it is subjected to different artifacts. Combining pharmacologic stress with submaximal exercise reduces side effects, improves image quality, and enhances the...

[ 4 ] - A quarter of a century with Iranian Journal of Nuclear Medicine

[ 5 ] - Factors affecting the quality of life of well-differentiated thyroid carcinoma patients: A cross-sectional study on 435 Iranian patients

Introduction: Differentiated thyroid carcinoma (DTC) is associated with excellent prognosis and high survival rates. This study was conducted to evaluate the influence of baseline and treatment-related factors on the health related quality of life (QoL) in cured DTC. Methods:This study was an analytic cross-sectional study on radio-iodine (RAI) treated DT...

[ 6 ] - Two-day stress-rest lower limbs perfusion scan in patients referred for myocardial perfusion imaging

Introduction: Peripheral Vascular Disease (PVD) is a major cause of morbidity and is associated with Coronary Artery Disease (CAD). We aimed to perform Lower Limb Perfusion Scan (LLPS) in patients referred for Myocardial Perfusion Imaging (MPI) and estimate prevalence of PVD in subgroups with normal and abnormal MPI results. We also compared quantitative indices of LLPS in pati...

[ 7 ] - Spinal cord metastasis from testicular seminoma detected by F-18 FDG PET/CT study prior to neurological symptoms: An unusual presentation

A 60-year-old patient with testicular seminoma was referred for F-18 FDG PET/CT Study to evaluate recurrence. In addition to hypermetabolic cervical, mediastinal and hilar lymph node tumoral metastases, segmental intense FDG uptake along the lumbar spinal cord suggestive of tumoral metastasis was noted which quite an unusual presentation is.  At the time of PET study the patient was symptomless...

[ 8 ] - Additive clinical value of bone scintigraphy in patients with malignant tumors with absence of localized bone pain: A report on most common sex-related cancers

  Introduction: Almost all malignant tumors have the potential to eventually produce bone metastasis. The aim of the current study was to report the distribution pattern and imaging characteristics of bone metastases detected by conventional whole body bone scintigraphy in patients with different types of malignancies and to assess their relationship with the complain...

[ 9 ] - Radioiodine therapy for hyperthyroidism

Radioiodine therapy is the safest, simplest, least expensive and most effective method for treatment of hyperthyroidism. The method employed in this research was a systematic bibliographic review, in which only valid studies or the clinically detailed enough open-labeled studies using validated scales were used. Iodine-131 (I-131) acts by the destructive effect of short-range beta radiation on ...

[ 10 ] - Evaluation of 99mTc-Ubiquicidin 29-41 scintigraphyin in differentiation of bacterial infection from sterile inflammationin diabetic foot

  Introduction: Ubiquicidin (UBI) 29-41 is a synthetic antimicrobial peptide that binds with the microbial cell membrane at the location of infection. This study was conducted to evaluate its probable efficacy as an infection-imaging agent with potential to differentiate bacterial infection from sterile inflammation in humans. Methods: Fifteen diabetic foot patients ...

[ 11 ] - Bone scan with incidental visualization of the entire colon

  A 57-year-old male with history of prostatectomy, cyctectomy, cecal urinary diversion for invasive prostate cancer and with a recent rise in PSA level, was referred for bone scintigraphy to rule out osseous metastatic disease. An interesting finding was abnormal tracer accumulation throughout the large bowel, which was proved to be due to urinary diversion.

[ 12 ] - The value of myocardial perfusion imaging with Tc-99m MIBI for the prediction of perfusion improvement after percutaneous transluminal coronary angioplasty

  Introduction: Percutaneous transluminal coronary angioplasty (PTCA) is an effective method for revascularizing of stenotic coronary vessels. Lack of response to this treatment, either in symptomatic or asymptomatic patients, is usually due to incomplete revascularization, restenosis, and/or irreversibility of myocardial perfusion. Introduction of a noninvasive metho...

[ 13 ] - McCune-Albright syndrome: Report of a case

  A 29- year old female with bone pain and history of precocious puberty was referred for bone scintigraphy. On physical examination café au lait macular spots were noted on her neck, buttocks and left leg. Bone scan showed multiple areas of intense increased activity which was in favour of polyostotic fibrous dysplasia. Considering the presence of polyostotic fibrous...

[ 14 ] - The pattern of brain perfusion SPECT in non-medicated schizophrenic patients

  Introduction: Studies with single photon emission computed tomography (SPECT) have revealed inconsistent changes of regional cerebral blood flow (rCBF) in schizophrenia. Some studies investigated the rCBF and its relationship with psychopathology, positive and negative symptoms in treated patients. However, there is a little information about the pattern of rCBF in ...

[ 15 ] - The first experience of stem cell labeling in Iran using 111In- Oxine [Persian]

  Introduction: The field of stem cell biology and regenerative medicine is rapidly moving toward translation to clinical practice. Stem cell therapy seems to be a new treatment option for some diseases. So, tracking the distribution of stem cells is crucial to their therapeutic use. Based on this fact we labeled human mesenchymal stem cells (MSCs) with 111...

[ 16 ] - Myocardial perfusion scan accuracy in detection of coronary artery disease - Comparison with exercise stress test [Persian]

Introduction: In patients with coronary artery disease (CAD) noninvasive evaluation for detection of ischemia is important to avoid invasive interventions like angiography. Exercise stress test is conventionally the first study used in evaluation of CAD. Considering the noninvasive nature of the myocardial perfusion scan, we decided to compare its accuracy with stress test. Methods: Patie...

[ 17 ] - Agreement of two methods of planar and SPECT scintigraphy with 99mTc- RBC in detection of liver hemangioma [Persian]

Introduction: Hemangiomas are the most frequent benign tumors of the liver and detecting them from metastasis or other malignant hepatic tumors is of outmost importance. 99mTc- RBC scan is highly specific and is the method of choice for this differentiation. This scintigraphy is performed in Planar and SPECT modes. These two procedures are in agreement most of the times, however since SPE...

[ 18 ] - Catheter related artifacts on bone scans: report of two cases

Bone scanning using the 99mTc-phosphate analogs is an established diagnostic modality and a commonly requested radioisotope examination for a variety of pathologies involving the skeleton, such as osteomyelitis, bony metastases, and occult fractures. The bone scan is one of the most commonly requested procedure in most nuclear medicine department. The images show areas of increased and de...

[ 19 ] - Radioiodine treatment effects on lacrimal glands function in patients with thyroid cancer [Persian]

  Introduction: There is a limited number of case reports published in the past decade confirming the radio-iodine presence in the tear. These observations as well as reported cases of salivary and lacrimal gland dysfunction after radioiodine therapy stimulated investigators to clarify whether lacrimal gland function can be affected post-radioiodine therapy. Hence we ...

[ 20 ] - Evaluation of ِdiagnostic role of 99mTc-Tetrofosmin scintigraphy in cold thyroid nodules [Persian]

Introduction: Various radiopharmaceuticals, including 67Ga, 201Tl, and 99mTc-sestamibi have been used to differentiate benign from malignant thyroid nodules. 99mTc-Tetrofosmin, a lipophilic cationic radiotracer, and 99mTc-sestamibi have also been reported to accumulate in thyroid tumors. In this study, we evaluated the role of 99mTc-Tetrofosmin in the differentiation of malignant from ben...

[ 21 ] - Accuracy of SPECT bone scintigraphy in diagnosis of meniscal tears

Introduction: Scintigraphy has been considered as a useful tool in the assessment of meniscal tears. Our objective was to assess the accuracy of single photon emission tomography (SPECT), using MRI as the gold standard, in the diagnosis of meniscal tears. Materials and Methods: Between January 2003 and February 2005, 45 patients were studied with SPECT and MRI. Results: The respective sen...

[ 22 ] - Radiopharmaceutical regulation worldwide - The resemblances and the differences [Persian]

A Radiopharmaceutical is a radioactive compound used for the diagnosis and treatment of human diseases. Radiopharmaceuticals are among the most highly regulated materials administered to patients because they are controlled both as drugs and as radioactive substances. The use of radiopharmaceuticals for any purpose is governed by regulatory agencies in different countries all over the wor...

[ 23 ] - Dystrophic calcinosis cutis and SLE; the bone scan pattern [Persian]

A 21 years old woman presented with a history of SLE and skin lesions on the arms, trunk, and abdomen. The left gluteal region was ulcerated and painful and occasionally extruded a chalky white material. The patient referred from rheumatology department for osteomyelitis assessment. On physical examination the patient had hard, nontender lesions on the proximal arms, lower abdomen and low...

[ 24 ] - The value of myocardial perfusion imaging in differentiating between idiopathic dilated cardiomyopathy from the ischemic form [Persian]

Introduction: Differentiating between ischemic cardiomyopathy (ICM) and idiopathic dilated cardiomyopathy (IDCM) is important as coronary revascularization can improve prognosis in the ischemic subgroup. Due to inherent problems of coronary angiography in patients with depressed ejection fraction (EF) introducing a noninvasive tool to diagnose those who will benefit from angiography seems...

[ 25 ] - Determination of radiation dose rates and urinary activity of patients received Sodium Iodide-131 for treatment of differentiated thyroid carcinoma [Persian]

Sodium Iodide-131 is administrated for treatment of hyperthyroidism and thyroid cancer. Iodine-131 has multiple routs of excretion (Urine, saliva, sweat, milk, feces, exhalation) from the body. Patients receiving Sodium Iodide-131 therapy exposes other persons and the environment to unwanted radiation and contamination. The major source of radiation dose from administration of Iodine-131 ...

[ 26 ] - The value of Tc-99m MIBI scintigraphy in active diseases and remission phase of multiple myeloma [Persian]

[ 27 ] - Reverse redistribution in the myocardial perfusion scan with ²º¹Tl [Persian]

Reverse redistribution pattern is defined as decreased activity in the myocardium in the rest phase of the myocardial perfusion scan in comparison with the stress images. There are many studies concerning the etiology and clinical significant of this phenomenon in nuclear medicine literature. The dominant idea about etiology of reverse redistribution is early wash out of the radiotracer f...

[ 28 ] - Effects of treatment with radioiodine (¹³¹I) on the gonadal function of the hyperthyroid patients

Introduction: Hyperthyroidism is a relatively common disorder caused by different etiologies. Graves’ disease, and toxic-nodular goiter (Plummer’s disease) are among the most common causes. Treatment with radioiodine is considered to be the treatment of choice in many of the patients. Higher biological half-life of ¹³¹I in hyperthyroid patients as compared with patients with differentiate...

[ 29 ] - Qualitative evaluation of Chang method of attenuation correction on heart SPECT by using custom made heart phantom

SPECT detects γ-rays from administered radiopharmaceutical within the patient body. γ-rays pass through different tissues before reaching detectors and are attenuated. Attenuation can cause artifacts; therefore different methods are used to minimize attenuation effects. In our study efficacy of Chang method was evaluated for attenuation purpose, using a custom made heart phantom. Due to d...

[ 30 ] - ¹³¹I-MIBG scintigraphy in Carcinoid tumor with liver metastases (Case report) [Persian]

A 65 years old male presented with abdominal pain (R.U.Q) and constipation, associated with weight loss and anorexia since 40 days prior to admission. Serum biochemical tests were normal. Colonoscopy showed hemorrhagic polypoid lesion in the cecum. Barium enema revealed filling defect in the cecum. Sonography revealed a target-shaped lesion (3cm×2.5cm) in upper segment of the right hepati...

[ 31 ] - Gamma scintigraphy in the evaluation of drug delivery systems [Persian]

Gamma-scintigraphy is applied extensively in the development and evaluation of pharmaceutical delivery systems, particularly for monitoring formulations in the gastrointestinal and respiratory tracts. The radiolabelling is generally achieved by the incorporation of an appropriate radionuclide such as technetium-99m or indium-111 into the formulation or by addition of a non-radioactive iso...

[ 32 ] - Contamination monitoring of Na¹³¹I levels in therapy unit of Research Institute for Nuclear Medicine, Tehran University of Medical Sciences by indirect method (Wipe test) [Persian]

Contamination with radiopharmaceuticals in nuclear medicine centers in addition to being a health concern requires time-consuming decontamination efforts. According to NRC (Nuclear Regulatory Commission) contamination should be monitored in nuclear medicine centers where radiopharmaceuticals are prepared and administrated at the end of each working session; otherwise, contamination spread...

[ 33 ] - Radioiodine therapy effects on salivary gland function in patients with differentiated thyroid cancer [Persian]

Salivary gland involvement is one of the radioiodine therapy complications. Salivary gland scintigraphy in quantitative mode can accurately evaluate salivary gland function. Methods: Salivary gland scintigraphy was performed with Tc-99m Pertechnetate, at the time of iodine therapy as a basic study and then 3 weeks and 3 months afterwards. Ejection Fraction (EF) of parotid and submandibula...

[ 34 ] - Novel and efficient method for solid phase synthesis of urea-containing peptides targeting prostate specific membrane antigen (PSMA) in comparison with current methods

The basic chemical structure of most prostate specific membrane antigen (PSMA) inhibitors which are now in pre-clinical and clinical studies is Glu-Ureido-based peptides. Synthesis of urea-based PSMA inhibitors includes two steps: 1- isocyanate intermediate formation and 2- urea bond formation. In current methods, isocyanate is formed in liquid phase and then reacts with amine existing in liqui...

[ 35 ] - A 99mTc-tricine-HYNIC-labeled Peptide Targeting the Melanocortin-1 Receptor for Melanoma Imaging

Melanocortin-1 (MC1) receptor is an attractive melanoma-specific target for the development of α-MSH peptide based imaging and therapeutic agents. In this work a new lactam bridge α-MSH analogue was synthesized and radiolabeled with 99mTc via HYNIC chelator and tricine as co-ligand. Also, stability in human serum, receptor bound internalization and tissue biodistribution in tumor bearing nude m...

[ 36 ] - Synthesis, Radiolabeling, and Biological Evaluation of Peptide LIKKPF Functionalized with HYNIC as Apoptosis Imaging Agent

Introduction: A noninvasive method of detecting exposure of phosphatidylserine (PS) on the external surface of the plasma membrane such as nuclear imaging could assist the diagnosis and therapy of apoptosis related pathologies. The most studied imaging agent for apoptosis is Annexin V so far. Because of limitations of Annexin V other agents have been introduced such as small peptides and molecu...

[ 37 ] - Synthesis and Preliminary Evaluation of a New 99mTc Labeled Substance P Analogue as a Potential Tumor Imaging Agent

Neurokinin 1 receptors (NK1R) are overexpressed on several types of important human cancer cells. Substance P (SP) is the most specific endogenous ligand known for NK1Rs. Accordingly, a new SP analogue was synthesized and evaluated for detection of NK1R positive tumors. [6-hydrazinopyridine-3-carboxylic acid (HYNIC)-Tyr8-Met(O)11-SP] was synthesized and radiolabeled with 99mTc using ethylenedia...

[ 38 ] - Optimum Conditions of Radioligand Receptor Binding Assay of Ligands of Benzodiazepine Receptors

To obtain drugs which are more selective at benzodiazepine (BZD) receptors, design and synthesis of functionally selective ligands for BZD receptors is the current strategy of our pharmaceutical chemistry department. The affinity of newly synthesized ligands is assessed by radioligand receptor binding assays. Based on our previous studies, 2-phenyl-5-oxo-7-methyl-1,3,4-oxadiazolo[a,2,3]-pyrimid...

[ 39 ] - 99mtc-Ubiquicidin [29–41], a Promising Radiopharmaceutical to Differentiate Orthopedic Implant Infections from Sterile Inflammation

Ubiquicidin (UBI) [29-41] is a synthetic cationic antimicrobial peptide that preferentially binds to bacterial cell membrane at the site of infection. We aimed to assess diagnostic value of 99mTc-UBI [29-41] as a radiopharmaceutical in differentiation of bacterial infection from sterile inflammation in suspected orthopedic implants. Nine patients suspected for orthopedic implant infection, all ...

[ 40 ] - Novel and efficient method for solid phase synthesis of urea-containing peptides targeting prostate specific membrane antigen (PSMA) in comparison with current methods

The basic chemical structure of most prostate specific membrane antigen (PSMA) inhibitors which are now in pre-clinical and clinical studies is Glu-Ureido-based peptides. Synthesis of urea-based PSMA inhibitors includes two steps: 1- isocyanate intermediate formation and 2- urea bond formation. In current methods, isocyanate is formed in liquid phase and then reacts with amine existing in liqui...

[ 41 ] - A 99mTc-tricine-HYNIC-labeled Peptide Targeting the Melanocortin-1 Receptor for Melanoma Imaging

Melanocortin-1 (MC1) receptor is an attractive melanoma-specific target for the development of α-MSH peptide based imaging and therapeutic agents. In this work a new lactam bridge α-MSH analogue was synthesized and radiolabeled with 99mTc via HYNIC chelator and tricine as co-ligand. Also, stability in human serum, receptor bound internalization and tissue biodistribution in tumor bearing nude m...

[ 42 ] - Synthesis, Radiolabeling, and Biological Evaluation of Peptide LIKKPF Functionalized with HYNIC as Apoptosis Imaging Agent

Introduction: A noninvasive method of detecting exposure of phosphatidylserine (PS) on the external surface of the plasma membrane such as nuclear imaging could assist the diagnosis and therapy of apoptosis related pathologies. The most studied imaging agent for apoptosis is Annexin V so far. Because of limitations of Annexin V other agents have been introduced such as small peptides and molecu...

[ 43 ] - Synthesis and Preliminary Evaluation of a New 99mTc Labeled Substance P Analogue as a Potential Tumor Imaging Agent

Neurokinin 1 receptors (NK1R) are overexpressed on several types of important human cancer cells. Substance P (SP) is the most specific endogenous ligand known for NK1Rs. Accordingly, a new SP analogue was synthesized and evaluated for detection of NK1R positive tumors. [6-hydrazinopyridine-3-carboxylic acid (HYNIC)-Tyr8-Met(O)11-SP] was synthesized and radiolabeled with 99mTc using ethylenedia...

[ 44 ] - Optimum Conditions of Radioligand Receptor Binding Assay of Ligands of Benzodiazepine Receptors

To obtain drugs which are more selective at benzodiazepine (BZD) receptors, design and synthesis of functionally selective ligands for BZD receptors is the current strategy of our pharmaceutical chemistry department. The affinity of newly synthesized ligands is assessed by radioligand receptor binding assays. Based on our previous studies, 2-phenyl-5-oxo-7-methyl-1,3,4-oxadiazolo[a,2,3]-pyrimid...

[ 45 ] - 99mtc-Ubiquicidin [29–41], a Promising Radiopharmaceutical to Differentiate Orthopedic Implant Infections from Sterile Inflammation

Ubiquicidin (UBI) [29-41] is a synthetic cationic antimicrobial peptide that preferentially binds to bacterial cell membrane at the site of infection. We aimed to assess diagnostic value of 99mTc-UBI [29-41] as a radiopharmaceutical in differentiation of bacterial infection from sterile inflammation in suspected orthopedic implants. Nine patients suspected for orthopedic implant infection, all ...

[ 46 ] - درمان تومورهای غددی-عصبی با I-131 Metaiodobenzylguanidine (I-131 MIBG)

زمینه: کاربرد رادیودارویI-131 MIBG در درمان تومورهای با منشأ غددی- عصبی، خصوصاً از نوع نورواکتودرمال (سمپاتوآدرنال) شامل فئوکروموسیتوم، پاراگانگلیوم و نوروبلاستوم مؤثر بوده است. در سایر تومورهای غددی- عصبی (عمدتاً کارسینوئید و کارسینوم مدولاری تیروئید) نیز این درمان گاهی می‌تواند مؤثر واقع گردد. مواد و روش‌ها: در این مطالعه مروری، کارآزمایی‌های بالینی شاهد - موردی و همچنین مطالعات باز که دارای اع...

[ 47 ] - Synthesis and radioprotective study of novel amino-alkyldithiocarbamic acid derivatives against γ-irradiation in mice

Background: The aim of this study was to evaluate the radioprotective capacity of some novel aminoalkylated dithiocarbamic acid potassium salts against γ-irradiation in mice. Materials and Methods: Eight compounds containing 2-aminoethyl-, 3- aminopropyl-, 4-aminobutyl-, 5-aminopentyl-, 6- aminohexyl-, 7-aminoheptyl-, 8-aminooctyl and 9- aminononyl of dithiocarbamate derivatives were prepared. ...

[ 48 ] - Diagnostic efficiency of 68Ga-DOTATATE PET/CT as compared to 99mTc-Octreotide SPECT/CT and conventional morphologic modalities in neuroendocrine tumors

Objective(s): In view of somatostatin receptor (SSR) expression on cell membranes of the majority of neuroendocrine tumors (NETs), functional imaging exploiting analogs of SSR alongside the anatomical imaging is the mainstay of this diagnostic modality. In this prospective study, we assessed and directly compared the diagnostic parameters of 68Ga-DOTATATE PET/CT and 99...

[ 49 ] - 68Ga-DOTATATE PET/CT Compared with 131I-MIBG SPECT/CT in the Evaluation of Neural Crest Tumors

Objective(s): 68Ga-DOTATATE positron emission tomography (PET)/computed tomography (CT) has shown promising results in imaging of neural crest tumors (NCT). Herein, we compared the performance of 68Ga-DOTATATE PET/CT and 131I-MIBG single photon emission computed tomography (SPECT)/CT in the initial diagnosis, staging and follow-up of pa...

[ 50 ] - Preclinical study of a new 177Lu-labeled somatostatin receptor antagonist in HT-29 human colorectal cancer cells

Objective(s): Somatostatin receptor-positive neuroendocrine tumors have been targeted using various peptide analogs radiolabeled with therapeutic radionuclides for years. The better biomedical properties of radioantagonists as higher tumor uptake make these radioligands more attractive than agonists for somatostatin receptor-targeted radionuclide therapy. In this study...

[ 51 ] - Disseminated thoracoabdominal splenosis mimicking metastatic disease: A case of colorectal cancer

Here, we describe a patient with a history of colorectal cancer in whom 2-[18F]fluoro-2-deoxy-D-glucose positron emission tomography/computed tomography ([18F]FDG PET/CT) was performed for the evaluation of response to therapy. [18F]FDG PET/CT showed a small residual disease in the rectum. In addition, multiple metabolically inactive soft tissue densities were d...